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Gnetol

Gnetol 是从买麻藤的根中分离出来的一种酚类。它是酪氨酸酶抑制剂，对鼠酪氨酸酶的 IC50为 4.5 μM，可抑制黑色素的生物合成。它有效抑制 COX-1和 HDAC，具有抗氧化、抗增殖、抗癌和保肝活性，还具有浓度依赖性的 α-淀粉酶、α-葡萄糖苷酶和脂肪形成活性。

CAS号

86361-55-9

分子式

C14H12O4

主要靶点

HDAC|COX|AChR|Tyrosinase

仅限科研使用

Cat No : CM06819

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Synonyms

验证数据展示

  • CAS No.: 86361-55-9

    Gnetol
    CAS#: 86361-55-9

产品信息

Gnetol competitivity inhibits butyrylcholinesterase (IC50: 1.3 uM). Gnetol has a strong inhibitory effect on murine tyrosinase activity. Gnetol significantly suppresses melanin biosynthesis in murine B16 melanoma cells. It is active in the inhibition of arachidonic acid (AA)-induced platelet aggregation.

CAS号 86361-55-9
分子式 C14H12O4
主要靶点 HDAC|COX|AChR|Tyrosinase
主要通路 神经科学|免疫与炎症|DNA损伤和修复|蛋白酶体|表观遗传
分子量 244.24
纯度 98.55%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名

靶点活性

butyrylcholinesterase:1.3 μM

溶解度

DMSO:45 mg/mL (184.24 mM)

参考文献

1.Ohguchi K, et al. Gnetol as a potent tyrosinase inhibitor from genus Gnetum.[J]. Journal of the Agricultural Chemical Society of Japan, 2003, 67(3):663-665.
2.Kloypan C, et al. Stilbenoids from Gnetum macrostachyum Attenuate Human Platelet Aggregation and Adhesion[J]. Phytotherapy Research, 2012, 26(10):1564-1568.
3.Sermboonpaisarn T, Sawasdee P. Potent and selective butyrylcholinesterase inhibitors from Ficus foveolata.[J]. Fitoterapia, 2012, 83(4):780-784.

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