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H-151

H-151 是选择性和共价的STING 拮抗剂，可减少 TBK1 磷酸化并抑制 STING 棕榈酰化，在体内外均具有显著的抑制活性，可用于自身炎症性疾病的研究。

CAS号

941987-60-6

分子式

C17H17N3O

主要靶点

STING

仅限科研使用

Cat No : CM01657

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Synonyms

验证数据展示

  • CAS No.: 941987-60-6

    H-151
    CAS#: 941987-60-6

产品信息

H-151 is a highly potent, selective and covalent antagonist of STING, reduces TBK1 phosphorylation and suppresses human STING palmitoylation.

CAS号 941987-60-6
分子式 C17H17N3O
主要靶点 STING
主要通路 免疫与炎症
分子量 279.34
纯度 99.52%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名

溶解度

DMSO:125 mg/mL (447.48 mM),Sonification is recommended.

参考文献

1.Haag S M , Gulen M F , Luc R , et al. Targeting STING with covalent small-molecule inhibitors[J]. Nature, 2018.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
=
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
×
=
×
C1   V1   C2   V2