验证数据展示
产品信息
12863-1-PBS targets HABP2 in IHC, Indirect ELISA applications and shows reactivity with human samples.
经测试应用 | IHC, Indirect ELISA Application Description |
经测试反应性 | human |
免疫原 | HABP2 fusion protein Ag3981 种属同源性预测 |
宿主/亚型 | Rabbit / IgG |
抗体类别 | Polyclonal |
产品类型 | Antibody |
全称 | hyaluronan binding protein 2 |
别名 | |
计算分子量 | 560 aa, 63 kDa |
GenBank蛋白编号 | BC031412 |
基因名称 | HABP2 |
Gene ID (NCBI) | 3026 |
RRID | AB_10640521 |
偶联类型 | Unconjugated |
形式 | Liquid |
纯化方式 | Antigen affinity purification |
UNIPROT ID | Q14520 |
储存缓冲液 | PBS only , pH 7.3 |
储存条件 | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
HABP2 is also named as HGFAL, PHBP and belongs to the peptidase S1 family. It can activate coagulation factor VII and prourokinase and release the vasoactive peptide bradykinin by cleaving kininogen and is an important role in the regulation of the haemostasis system as well as fibroproliferative inflammatory processes (PMID:21655671). HABP2 is present as the 70 kDa inactive single chain precursor in human plasma and transforms to the active two chain form, 50 kDa heavy chain and 27 kDa light chain,and the 50 kDa heavy chain changes to two 26 kDa fragments, and 27 kDa light chain to 17 kDa and 8 kDa fragments, which are all bridged by disulfide linkages, by autocleavage(PMID:11217080).