验证数据展示
产品信息
82899-2-PBS targets HLA-DMA in Indirect ELISA, IHC, WB applications and shows reactivity with Human samples.
Tested Applications | WB, IHC, Indirect ELISA Application Description |
Tested Reactivity | Human |
Immunogen | HLA-DMA fusion protein Ag2452 种属同源性预测 |
Host / Isotype | Rabbit / IgG |
Class | Recombinant |
Type | Antibody |
Full Name | major histocompatibility complex, class II, DM alpha |
Synonyms | hCG_2001572, DMA protein MHC class II antigen Major histocompatibility complex, class II, DM alpha cDNA FLJ75740, highly similar to Homo sapiens major histocompatibility complex, class II, DM alpha, DMA protein, DMA, D6S222E |
Calculated Molecular Weight | 261 aa, 29 kDa |
Observed Molecular Weight | 30 kDa |
GenBank Accession Number | BC026279 |
Gene Symbol | HLA-DMA |
Gene ID (NCBI) | 3108 |
Conjugate | Unconjugated |
Form | Liquid |
Purification Method | Protein A purification |
UNIPROT ID | Q31604 |
Storage Buffer | PBS Only |
Storage Conditions | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
Human major histocompatibility complex (MHC) antigens, also referred to as human leukocyte antigens (HLA), are encoded by genes located on the short arm of chromosome 6 (6p21.3). There are two classes of HLA antigens: class I (HLA-A, B and C) and class II (HLA-D). The class II molecules are composed of two non-covalently associated alpha and beta chains. HLA-DMA and HLA-DMB form a functional heterodimer that is critical in the pathway of class II antigen presentation. HLA-DM plays a critical role in catalyzing the release of Class II HLA-associated invariant chain-derived peptides (CLIP) from newly synthesized class II HLA molecules and freeing the peptide binding site for acquisition of antigenic peptides.