HLA-E Monoclonal antibody, PBS Only

HLA-E Monoclonal Antibody for WB, IHC, IF-P, Indirect ELISA
Cat No. 66530-1-PBS

产品说明书

CloneNo. 1A4G3

宿主/亚型

Mouse / IgG2a

种属反应性

Human

应用

WB, IHC, IF-P, Indirect ELISA

EA1.2, EA2.1, HLA 6.2, HLA E, HLAE, HLA-E, MHC, MHC class I antigen E, QA1

缓冲液配方:  PBS Only
PBS and Azide
PBS Only
偶联物:  Unconjugated
规格: 

-/ -


Planning an IHC experiment? We recommend our IHCeasy HLA-E Ready-To-Use IHC Kit. HLA-E primary antibody included.

产品信息

66530-1-PBS targets HLA-E in WB, IHC, IF-P, Indirect ELISA applications and shows reactivity with Human samples.

经测试应用 WB, IHC, IF-P, Indirect ELISA Application Description
经测试反应性 Human
免疫原 HLA-E fusion protein Ag6724 种属同源性预测
宿主/亚型 Mouse / IgG2a
抗体类别 Monoclonal
产品类型 Antibody
全称 major histocompatibility complex, class I, E
别名 EA1.2, EA2.1, HLA 6.2, HLA E, HLAE, HLA-E, MHC, MHC class I antigen E, QA1
计算分子量 40 kDa
观测分子量 40 kDa
GenBank蛋白编号BC002578
基因名称 HLA-E
Gene ID (NCBI) 3133
RRIDAB_2881893
偶联类型 Unconjugated
形式 Liquid
纯化方式Protein A purification
UNIPROT IDP13747
储存缓冲液 PBS only , pH 7.3
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

Human major histocompatibility complex (MHC) antigens, also referred to as human leukocyte antigens (HLA), are encoded by genes located on the short arm of chromosome 6 (6p21.3). There are two classes of HLA antigens: class I and class II. This class I molecules are membrane glycoproteins composed of a heavy (alpha) chain which is encoded by a HLA class I gene, and β2-microglobulin light (beta) chain. The most extensively characterized members of the HLA class I gene family are the genes encoding the major transplantation antigenes, HLA-A, B and C. HLA-E is a non-classical MHC class I molecule. HLA-E is frequently overexpressed in tumor diseases, transplants and virus-infected cells and represents an immunomodulatory molecule by binding to the receptors CD94/NKG2A, -B and -C on NK and T cells. Due to its immune suppressive features HLA-E expression might represent an important mechanism of tumors to escape immune surveillance.(PMID: 667938; 3375250; 2249951; 27589686)

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