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验证数据展示

  • WB analysis of human testis using 67091-1-Ig (same clone as 67091-1-PBS)

    WB analysis of human testis using 67091-1-Ig (same clone as 67091-1-PBS)

    human testis tissue were subjected to SDS PAGE followed by western blot with 67091-1-Ig (HORMAD1 antibody) at dilution of 1:4000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 67091-1-PBS in a different storage buffer formulation.

  • IHC staining of human breast cancer using 67091-1-Ig (same clone as 67091-1-PBS)

    IHC staining of human breast cancer using 67091-1-Ig (same clone as 67091-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human breast cancer tissue slide using 67091-1-Ig (HORMAD1 antibody) at dilution of 1:400 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 67091-1-PBS in a different storage buffer formulation.

  • IF Staining of HepG2 using 67091-1-Ig (same clone as 67091-1-PBS)

    IF Staining of HepG2 using 67091-1-Ig (same clone as 67091-1-PBS)

    Immunofluorescent analysis of (4% PFA) fixed HepG2 cells using 67091-1-Ig (HORMAD1 antibody) at dilution of 1:100 and CoraLite488-Conjugated Goat Anti-Mouse IgG(H+L). This data was developed using the same antibody clone with 67091-1-PBS in a different storage buffer formulation.

  • Featured Product
  • KD/KO Validated

HORMAD1 Monoclonal antibody, PBS Only

HORMAD1 Monoclonal Antibody for WB, IHC, IF/ICC, Indirect ELISA
Cat No. 67091-1-PBS
CloneNo. 2D7E12

Host / Isotype

Mouse / IgG1

Reactivity

Human, mouse

Applications

WB, IHC, IF/ICC, Indirect ELISA

Synonyms

Cancer/testis antigen 46, CT46, DKFZp434A1315, HORMA domain containing 1, HORMAD1, Newborn ovary HORMA protein, NOHMA, RP11 363I22.1

Formulation:  PBS Only
PBS and Azide
PBS Only
Conjugate:  Unconjugated
Size: 

-/ -

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产品信息

67091-1-PBS targets HORMAD1 in WB, IHC, IF/ICC, Indirect ELISA applications and shows reactivity with Human, mouse samples.

Tested Applications WB, IHC, IF/ICC, Indirect ELISA Application Description
Tested Reactivity Human, mouse
Immunogen HORMAD1 fusion protein Ag28316 种属同源性预测
Host / Isotype Mouse / IgG1
Class Monoclonal
Type Antibody
Full Name HORMA domain containing 1
Synonyms Cancer/testis antigen 46, CT46, DKFZp434A1315, HORMA domain containing 1, HORMAD1, Newborn ovary HORMA protein, NOHMA, RP11 363I22.1
Calculated Molecular Weight 45 kDa
Observed Molecular Weight 50-55 kDa
GenBank Accession NumberBC047406
Gene Symbol HORMAD1
Gene ID (NCBI) 84072
RRIDAB_2882396
Conjugate Unconjugated
Form Liquid
Purification MethodProtein G purification
UNIPROT IDQ86X24
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

HORMA domain-containing proteins regulate interactions between homologous chromosomes (homologs) during meiosis in a wide range of eukaryotes [PMID:21079677]. They also implicated in other processes related to crossover formation, including DSB formation, inhibition of promiscuous formation of the synaptonemal complex (SC), and the meiotic prophase checkpoint that monitors both DSB processing and SCs [PMID:19851446]. HORMAD1 first accumulates on the chromosomes during the leptotene to zygotene stages of meiotic prophase I. As germ cells progress into the pachytene stage, HORMAD1 disappears from the synapsed chromosomal regions. However, once the chromosomes desynapse during the diplotene stage, HORMAD1 again accumulates on the chromosome axis of the desynapsed homologs [PMID:19686734].