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HYAL1 Polyclonal antibody, PBS Only

HYAL1 Polyclonal Antibody for WB, IHC, Indirect ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse

Applications

WB, IHC, Indirect ELISA

Conjugate

Unconjugated

Cat no : 25179-1-PBS

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Synonyms

验证数据展示

  • WB analysis using 25179-1-AP (same clone as 25179-1-PBS)

    WB analysis using 25179-1-AP (same clone as 25179-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 25179-1-AP (HYAL1 antibody) at dilution of 1:4000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 25179-1-PBS in a different storage buffer formulation.

  • IHC staining of mouse liver using 25179-1-AP (same clone as 25179-1-PBS)

    IHC staining of mouse liver using 25179-1-AP (same clone as 25179-1-PBS)

    Immunohistochemical analysis of paraffin-embedded mouse liver tissue slide using 25179-1-AP (HYAL1 antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 25179-1-PBS in a different storage buffer formulation.

  • IHC staining of mouse liver using 25179-1-AP (same clone as 25179-1-PBS)

    IHC staining of mouse liver using 25179-1-AP (same clone as 25179-1-PBS)

    Immunohistochemical analysis of paraffin-embedded mouse liver tissue slide using 25179-1-AP (HYAL1 antibody) at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 25179-1-PBS in a different storage buffer formulation.

产品信息

25179-1-PBS targets HYAL1 in WB, IHC, Indirect ELISA applications and shows reactivity with human, mouse samples.

Tested Applications WB, IHC, Indirect ELISA Application Description
Tested Reactivity human, mouse
Immunogen HYAL1 fusion protein Ag17943 种属同源性预测
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Full Name hyaluronoglucosaminidase 1
Synonyms
Calculated Molecular Weight 435 aa, 48 kDa
Observed Molecular Weight 60 kDa
GenBank Accession NumberBC035695
Gene Symbol HYAL1
Gene ID (NCBI) 3373
RRIDAB_2879945
Conjugate Unconjugated
Form Liquid
Purification MethodAntigen affinity purification
UNIPROT IDQ12794
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

Hyaluronic acid (HA) is a glycosaminoglycan that is believed to have numerous important biologic functions, including modulation of cell proliferation, migration, and differentiation, as well as the regulation of extracellular water and protein homeostasis. It is also an integral structural component of cartilage and other tissues and acts as a lubricant in joints. Hyaluronidases are a family of enzymes that catalyse the degradation of HA. In humans, there are five functional hyaluronidases: HYAL1, HYAL2, HYAL3, HYAL4 and HYAL5 (also known as SPAM1 or PH-20); plus a pseudogene, HYAL6 (also known as HYALP1). HYAL-1 is present in many tissues and is predominantly found in the plasma and urine (PMID: 16600643). In addition to its function in normal cellular hyaluronan turnover, human HYAL-1 is implicated in cancer proliferation, angiogenesis, and inflammatory diseases (PMID: 17503783).