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Hemin

Hemin (Hemin chloride) 是一种含铁卟啉和血红素加氧酶 (HO)-1 诱导剂。

CAS号

16009-13-5

分子式

C34H32ClFeN4O4

主要靶点

Mitophagy|Autophagy|Ferroptosis

仅限科研使用

Cat No : CM00291

Print datasheet

Synonyms

氯化血红素|Hemin chloride

验证数据展示

  • CAS No.: 16009-13-5

    Hemin
    CAS#: 16009-13-5

产品信息

Hemin is an iron-containing porphyrin and Heme oxygenase (HO)-1 inducer.

CAS号 16009-13-5
分子式 C34H32ClFeN4O4
主要靶点 Mitophagy|Autophagy|Ferroptosis
主要通路 自噬|凋亡
分子量 651.94
纯度 99.59%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名 氯化血红素|Hemin chloride

体外活性

Hemin treatment decreased cell proliferation to 62±5 %, 51±3 %, and 38±8 % in PA-TU-8902, BxPC-3 and MiaPaCa-2 cancer cells, respectively, with p<0.0001 for all comparisons. Furthermore, we observed enhancement of anti-proliferative effects of statins by hemin, documented as decreased cell proliferation after 48 h of co-treatment[1][2].

溶解度

DMSO:6.5 mg/mL (10 mM)

细胞实验

In vitro effects of various statins and hemin, a heme oxygenase inducer, on cell proliferation were evaluated in PA-TU-8902, MiaPaCa-2 and BxPC-3 human pancreatic cancer cell lines. The effect of statins on heme oxygenase activity was assessed and heme oxygenase-silenced cells were used for pancreatic cancer cell proliferation studies. Cell death rate and reactive oxygen species production were measured in PA-TU-8902 cells, followed by evaluation of the effect of cerivastatin on GFP-K-Ras trafficking and expression of markers of invasiveness, osteopontin (SPP1) and SOX2[1].

参考文献

1.Vanova K , Boukalova S , Gbelcova H , et al. Heme oxygenase is not involved in the anti-proliferative effects of statins on pancreatic cancer cells[J]. BMC Cancer, 2016, 16(1):309.
2.Owen J E , Bishop G M , Robinson S R . Uptake and Toxicity of Hemin and Iron in Cultured Mouse Astrocytes[J]. Neurochemical Research, 2016.
3.Chen HH, et al. Heme oxygenase-1 ameliorates kidney ischemia-reperfusion injury in mice through extracellular signal-regulated kinase 1/2-enhanced tubular epithelium proliferation. Biochim Biophys Acta. 2015 Oct;1852(10 Pt A):2195-201.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
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C1   V1   C2   V2