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Recombinant Human Alpha-2-Macroglobulin protein (His Tag)

种属

Human

纯度

>90 %, SDS-PAGE

标签

His Tag

生物活性

未测试

Cat no : Eg1198

Print datasheet

Synonyms

A2M, Alpha 2 M, alpha 2 macroglobulin, Alpha 2M, Alpha-2-M

验证数据展示

  • Purity of Recombinant Human Alpha-2-Macroglobulin was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

    Purity of Recombinant Human Alpha-2-Macroglobulin was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

产品信息

纯度 >90 %, SDS-PAGE
内毒素 <0.1 EU/μg protein, LAL method
生物活性 Not tested
来源 HEK293-derived Human Alpha-2-Macroglobulin protein Ser24-Ala1474 (Accession# P01023) with a His tag at the C-terminus.
基因ID 2
蛋白编号 P01023
预测分子量 161.9 kDa
SDS-PAGE 120-200 kDa, reducing (R) conditions
组分 Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization.
复溶 Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water.
储存条件
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
  • Until expiry date, -20℃ to -80℃ as lyophilized proteins.
  • 3 months, -20℃ to -80℃ under sterile conditions after reconstitution.
运输条件 The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature.

背景信息

Alpha-2-Macroglobulin, also known as α2-macroglobulin (α2M or A2M), is a protein abundant in the plasma of vertebrates and several invertebrates. A2M is an evolutionarily conserved arm of the innate immune system. It also mediates the proliferation of T cells and macrophages. A2M acts as a nonspecific protease inhibitor involved in the host defense mechanism that inactivates both endogenous and exogenous proteases, including trypsin, thrombin and collagenase. Even though A2M is produced predominantly by the liver, it may also be expressed in the reproductive tract, heart, and brain, and may have important roles in many physiological processes and medical illnesses including Alzheimer's disease.

参考文献:

1. Jennifer Vandooren, Yoshifumi Itoh. (2021) Front Immunol. Dec 14:12:803244.
2. Jeremy Lagrange, et al. (2022) J Thromb Haemost. Apr;20(4):806-815.
3. Hongwei Zhang, et al. (2023) J Alzheimers Dis Rep. Dec 18;7(1):1351-1370.