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Recombinant Human CLEC10A/CD301 protein (rFc Tag)

种属

Human

纯度

>90 %, SDS-PAGE

标签

rFc Tag

生物活性

未测试

Cat no : Eg1892

Print datasheet

Synonyms

CLEC10A, CD301, CLECSF13, CLECSF14, C-type lectin domain family 10 member A

验证数据展示

  • Purity of Recombinant Human CLEC10A was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) conditions and stained using Coomassie blue.

    Purity of Recombinant Human CLEC10A was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) conditions and stained using Coomassie blue.

产品信息

纯度 >90 %, SDS-PAGE
内毒素 <0.1 EU/μg protein, LAL method
生物活性 Not tested
来源 HEK293-derived Human CLEC10A protein Gln61-His316 (Accession# Q8IUN9-1) with a rabbit IgG Fc tag at the N-terminus.
基因ID 10462
蛋白编号 Q8IUN9-1
预测分子量 56.0 kDa
SDS-PAGE 55-70 kDa, reducing (R) conditions
组分 Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization.
复溶 Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water.
储存条件
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
  • Until expiry date, -20℃ to -80℃ as lyophilized proteins.
  • 3 months, -20℃ to -80℃ under sterile conditions after reconstitution.
运输条件 The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature.

背景信息

C-type lectin domain family 10 member A (CLEC10A), also known as CD301, macrophage galactose-type C-type lectin (MGL), DC-asialoglyco protein receptor (DC-ASGP-R) or human macrophage lectin (HML), is a type II transmembrane glycoprotein having a calcium-dependent carbohydrate recognition domain. CLEC10A is expressed exclusively by myeloid professional antigen-presenting cells such as immature dendritic cells (DCs) and alternatively activated macrophages. CLEC10A is a marker for human CD1c+ DCs (cDC2). It functions as an endocytic receptor for glycosylated antigens.

参考文献:

1. Suzuki N. et al. (1996). J Immunol. 156(1):128-135.
2. Higashi N. et al. (2002). J Biol Chem. 277(23):20686-20693.
3. Valladeau J. et al. (2001). J Immunol. 167(10):5767-5774.
4. van Vliet SJ. et al. (2006). Nat Immunol. 7(11):1200-1208.
5. Heger L. et al. (2018). Front Immunol. 9:744.