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Recombinant Human FGF-21 protein (His Tag)

种属

Human

纯度

>90 %, SDS-PAGE

标签

His Tag

生物活性

未测试

Cat no : Eg0102

Print datasheet

Synonyms

FGF21, FGF-21, FGF 21, Fibroblast growth factor 21, UNQ3115/PRO10196

验证数据展示

  • Purity of Recombinant Human FGF-21 was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

    Purity of Recombinant Human FGF-21 was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

产品信息

纯度 >90 %, SDS-PAGE
内毒素 <0.1 EU/μg protein, LAL method
生物活性 Not tested
来源 HEK293-derived Human FGF-21 protein His29-Ser209 (Accession# Q9NSA1(L174P)) with a His tag at the N-terminus.
基因ID 26291
蛋白编号 Q9NSA1
预测分子量 20.2 kDa
SDS-PAGE 22-25 kDa, reducing (R) conditions
组分 Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization.
复溶 Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water.
储存条件
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
  • Until expiry date, -20℃ to -80℃ as lyophilized proteins.
  • 3 months, -20℃ to -80℃ under sterile conditions after reconstitution.
运输条件 The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature.

背景信息

Fibroblast growth factor 21 (FGF21) is a peptide hormone that is expressed across several tissues, predominantly in liver and adipocyte tissues, and, to a lower extent, in the pancreas, skeletal muscle, heart, kidneys and testes. FGF21 plays a role in regulating adaptation to various metabolic abnormalities. In the liver, FGF21 plays an important role in the regulation of fatty acid oxidation both in the fasted state and in mice consuming a high-fat, low-carbohydrate ketogenic diet. FGF21 also regulates fatty acid metabolism in mice consuming a diet that promotes hepatic lipotoxicity.

参考文献:

1. Fisher FM. et al.(2016) Annu Rev Physiol.
2. Strowski MZ. et al. (2017) Horm Mol Biol Clin Investig. 30(2).
3. Nishimura T. et al.(2000) Biochim Biophys Acta.1492(1):203-6.
4. Kharitonenkov A. et al. (2009) Curr Opin Investig Drugs.10(4):359-64.