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Recombinant Human FGFR3(IIIc) protein (His Tag)

ED50

/

Species

Human

Purity

>90 %, SDS-PAGE

GeneID

2261

Accession

P22607-1

Cat No : Eg1040

Print datasheet

Synonyms

FGFR3,ACH,CD333,CEK2,FGFR 3

验证数据展示

  • Purity of Recombinant Human FGFR3(IIIc) was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

    Purity of Recombinant Human FGFR3(IIIc) was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

Technical Specifications

Purity >90 %, SDS-PAGE
Endotoxin Level <1.0 EU/μg protein, LAL method
Biological Activity 
Not tested
Source HEK293-derived Human FGFR3(IIIc) protein Glu23-Gly375 (Accession# P22607-1) with a His tag at the C-terminus.
Predicted Molecular Mass 38.9 kDa
SDS-PAGE 50-70 kDa, reducing (R) conditions
Formulation Lyophilized from sterile PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization.
Reconstitution Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water.
Storage
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
  • Until expiry date, -20℃ to -80℃ as lyophilized proteins.
  • 3 months, -20℃ to -80℃ under sterile conditions after reconstitution.
Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature.

Background

Fibroblast growth factors (FGFs) are polypeptide growth factors involved in a variety of activities including mitogenesis, angiogenesis, and wound healing. The human FGF receptor family, a subfamily of receptor tyrosine kinases (RTKs), comprises of four family members-FGFR1, FGFR2, FGFR3, and FGFR4. Each receptor contains an extracellular domain with either two or three immunoglobulin-like domains, a transmembrane domain, and a cytoplasmic tyrosine kinase domain. FGFR3 plays a key role in different important physiological cellular processes such as regulation of cell growth, proliferation, angiogenesis, among the others. Moreover, FGFR3 binds acidic and basic fibroblast GH and plays a role in bone development and maintenance. Mutations in the FGFR3 gene lead to craniosynostosis and multiple types of skeletal dysplasia.

References:

1. K Keegan. et al. (1991). Proc Natl Acad Sci U S A. 88(4):1095-9.
2. Kai Hung Tiong. et al. (2013).  Apoptosis.18(12):1447-1468.
3. C Deng. et al. (1996). Cell.84(6):911-921.
4. Claudia Maria Ascione. et al. (2023). Cancer Treat Rev.115:102530.