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Recombinant Human IGFBP-1 protein (His Tag)

种属

Human

纯度

>90 %, SDS-PAGE

标签

His Tag

生物活性

未测试

Cat no : Eg0951

Print datasheet

Synonyms

IGFBP1, AFBP, hIGFBP 1, IBP 1, IBP1

验证数据展示

  • Purity of Recombinant Human IGFBP-1 was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

    Purity of Recombinant Human IGFBP-1 was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

产品信息

纯度 >90 %, SDS-PAGE
内毒素 <0.1 EU/μg protein, LAL method
生物活性 Not tested
来源 HEK293-derived Human IGFBP-1 protein Ala26-Asn259 (Accession# P08833) with a His tag at the C-terminus.
基因ID 3484
蛋白编号 P08833
预测分子量 26.1 kDa
SDS-PAGE 28-32 kDa, reducing (R) conditions
组分 Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization.
复溶 Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water.
储存条件
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
  • Until expiry date, -20℃ to -80℃ as lyophilized proteins.
  • 3 months, -20℃ to -80℃ under sterile conditions after reconstitution.
运输条件 The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature.

背景信息

IGFBP-1 (Insulin-like growth factor binding protein-1) belongs to the insulin-like growth factor (IGF) system, which plays an indispensable role in normal growth and development, and in the pathophysiology of various tumors. IGFBP-1 has been shown to be associated with the risk of various tumors, and has a vital function in regulating tumor behaviors such as proliferation, migration, invasion and adhesion through different molecular mechanisms. In addition, As a secreted protein, IGFBP-1 is the most predominant IGFBP in amniotic fluid and expressed steadily and normally in the liver, endometrium and placenta among them. But insulin that can inhibit IGFBP-1 expression through the insulin receptor and growth hormone can regulate IGFBP-1 expression.

参考文献:

1. Yi-Wei Lin. et al. ( 2021). Am J Transl Res. 13(3):813-832.
2. Linn Fagerberg. et al. (2014). Mol Cell Proteomics. 13(2):397-406.
3.T G Unterman. et al. (1991). Endocrinology.128(6):2693-2701.