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Recombinant Human LAMP3 protein (rFc Tag) (HPLC verified)

种属

Human

纯度

>90 %, SDS-PAGE
>90 %, SEC-HPLC

标签

rFc Tag

生物活性

未测试

Cat no : Eg3594

Print datasheet

Synonyms

CD208, DC LAMP, DCLAMP, DC-lysosome-associated membrane glycoprotein, LAMP

验证数据展示

  • Purity of Recombinant Human LAMP3 was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

    Purity of Recombinant Human LAMP3 was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

  • The purity of Human LAMP3 was greater than 90% as determined by SEC-HPLC.

    The purity of Human LAMP3 was greater than 90% as determined by SEC-HPLC.

产品信息

纯度 >90 %, SDS-PAGE
>90 %, SEC-HPLC
内毒素 <0.1 EU/μg protein, LAL method
生物活性 Not tested
来源 HEK293-derived Human LAMP3 protein Lys28-Thr381 (Accession# Q9UQV4) with a rabbit IgG Fc tag at the C-terminus.
基因ID 27074
蛋白编号 Q9UQV4
预测分子量 64.0 kDa
SDS-PAGE 80-120 kDa, reducing (R) conditions
组分 Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization.
复溶 Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water.
储存条件
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
  • Until expiry date, -20℃ to -80℃ as lyophilized proteins.
  • 3 months, -20℃ to -80℃ under sterile conditions after reconstitution.
运输条件 The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature.

背景信息

LAMP3 (lysosome-associated membrane protein 3), also known as DC-LAMP (DC-lysosome-associated membrane glycoprotein), TSC403, or CD208, is a highly glycosylated lysosomal membrane protein that belongs to the LAMP family. The mature glycoprotein has an apparent molecular mass of 70-90 kDa, which is considerably larger than its predicted mass of 44 kDa. LAMP3 is expressed in lung type II pneumocytes, lymphoid organs, and dendritic cells. It might change the lysosome function after the transfer of peptide-MHC class II molecules to the surface of dendritic cells. LAMP3 mRNA is up-regulated in some human cancers. LAMP3 overexpression is associated with an enhanced metastatic potential and may be a prognostic factor for cervical cancer.

参考文献:

1.de Saint-Vis B. et al. (1998). Immunity. 9(3):325-336.
2.Ozaki K. et al. (1998). Cancer Res. 58(16):3499-3503.
3.Kanao H. et al. (2005). Cancer Res. 65(19):8640-8645.