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Recombinant Human MICA protein (His Tag)

种属

Human

纯度

>90 %, SDS-PAGE

标签

His Tag

生物活性

未测试

Cat no : Eg1176

Print datasheet

Synonyms

MICA, MIC A, PERB11.1

验证数据展示

  • Purity of Recombinant Human MICA was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

    Purity of Recombinant Human MICA was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

产品信息

纯度 >90 %, SDS-PAGE
内毒素 <0.1 EU/μg protein, LAL method
生物活性 Not tested
来源 HEK293-derived Human MICA protein Glu24-Gln308 (Accession# AAH16929.1) with a His tag at the C-terminus.
基因ID 4276
蛋白编号 AAH16929.1
预测分子量 33.6 kDa
SDS-PAGE 45-60 kDa, reducing (R) conditions
组分 Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization.
复溶 Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water.
储存条件
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
  • Until expiry date, -20℃ to -80℃ as lyophilized proteins.
  • 3 months, -20℃ to -80℃ under sterile conditions after reconstitution.
运输条件 The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature.

背景信息

Human MHC class I chain-related genes located within the HLA class I region of chromosome 6 encode MHC class I chain-related A and B (MICA and MICB). MICA and MICB are stress-inducible surface molecules that are not associated with β2-microglobulin and do not present peptides. They are expressed in intestinal epithelium and many epithelial tumors. MICA and MICB are ligands for NKG2D which is an activating receptor that is expressed on most natural killer (NK) cells, CD8 αβ T cells, and γδ T cells.

参考文献:

1. V Groh, et al. (1998) Science. 279(5357):1737-40.
2. V Groh, et al. (1999) Proc Natl Acad Sci U S A. 96(12):6879-84.
3. S Bauer, et al. (1999) Science. 285(5428):727-9.
4. H A Stephens. (2001) Trends Immunol. 22(7):378-85.
5. A Steinle, et al. (2001) Immunogenetics. 53(4):279-87.