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Recombinant Human MUC17 protein (His Tag)

ED50

\

Species

Human

Purity

>90 %, SDS-PAGE

GeneID

140453

Accession

Q685J3-1

Cat No : Eg0413

Print datasheet

Synonyms

MUC17,MUC 17,MUC 3,MUC-17,MUC3

验证数据展示

  • Purity of Recombinant Human MUC17 was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) conditions and stained using Coomassie blue.

    Purity of Recombinant Human MUC17 was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) conditions and stained using Coomassie blue.

Technical Specifications

Purity >90 %, SDS-PAGE
Endotoxin Level <1.0 EU/μg protein, LAL method
Biological Activity 
Not tested
Source HEK293-derived Human MUC17 protein Arg4131-Leu4390 (Accession# Q685J3-1) with a His tag at the C-terminus.
Predicted Molecular Mass 12.6 kDa and 20.5 kDa
SDS-PAGE 17 kDa and 28-38 kDa, reducing (R) conditions
Formulation Lyophilized from sterile PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization.
Reconstitution Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water.
Storage
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
  • Until expiry date, -20℃ to -80℃ as lyophilized proteins.
  • 3 months, -20℃ to -80℃ under sterile conditions after reconstitution.
Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature.

Background

MUC17 is a membrane-bound mucin that provides protection to gut epithelial cells. MUC17 contains about 60 tandem repeats, with each repeat being around 60 aa.Membrane mucins, such as MUC17, function in epithelial cells to provide cytoprotection, maintain luminal structure, provide signal transduction, and confer antiadhesive properties upon cancer cells that lose their apical/basal polarization.

References:

1. Gum JR Jr, Crawley SC, Hicks JW, Szymkowski DE, Kim YS. MUC17, a novel membrane-tethered mucin. Biochem Biophys Res Commun. 2002;291(3):466-475.
2. Pelaseyed T, Bergström JH, Gustafsson JK, et al. The mucus and mucins of the goblet cells and enterocytes provide the first defense line of the gastrointestinal tract and interact with the immune system. Immunol Rev. 2014;260(1):8-20.