• All
  • Primary Antibodies
  • Conjugated Antibodies for IF
  • Conjugated Antibodies for FC
  • Secondary Antibodies
  • Antibody Labeling KitsNew
  • ELISA Kits
  • IHC Kits
  • Magnetic Cell Separation Kits
  • Cytokines & Growth Factors
  • Neutralizing/activating Antibodies
  • Nanobody-based Reagents
  • Accessory Products and Kits
  • Fusion Proteins
×
×
Host
0
Species Reactivity
0
Species Reactivity
0
Conjugate
0
Conjugate
0
Compatible Species
0
Conjugate
0

Recombinant Human Neuropilin-1 protein (rFc Tag)

种属

Human

纯度

>90 %, SDS-PAGE

标签

rFc Tag

生物活性

未测试

Cat no : Eg2331

Print datasheet

Synonyms

neuropilin 1, NRP1, BDCA4, CD304, Neuropilin-1

验证数据展示

  • Purity of Recombinant Human Neuropilin-1 was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

    Purity of Recombinant Human Neuropilin-1 was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

产品信息

纯度 >90 %, SDS-PAGE
内毒素 <0.1 EU/μg protein, LAL method
生物活性 Not tested
来源 HEK293-derived Human Neuropilin-1 protein Phe22-Lys644 (Accession# O14786-2) with a rabbit IgG Fc tag at the C-terminus.
基因ID 8829
蛋白编号 O14786-2
预测分子量 99.1 kDa
SDS-PAGE 90-120 kDa, reducing (R) conditions
组分 Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization.
复溶 Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water.
储存条件
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
  • Until expiry date, -20℃ to -80℃ as lyophilized proteins.
  • 3 months, -20℃ to -80℃ under sterile conditions after reconstitution.
运输条件 The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature.

背景信息

Neuropilin-1 (NRP1) is a transmembrane glycoprotein expressed by endothelial, dendritic, and regulatory T cells, as well as several other normal cell types and malignant tumor cells. NRP1 has been demonstrated to play a role in the stability and function of Tregs. It interacts with the ligand Semaphorin-4a (Sema4a) expressed on Tregs to enhance the function and survival of Tregs in tumors, restricting the anti-tumor immune response. NRP1 was also shown to act as a receptor for vascular endothelial growth factor (VEGF) and a promoter of angiogenesis through its interaction with VEGF-A165 (and other VEGFs) and the receptor tyrosine kinase (RTK) VEGF-R2. In summary, NRP1 is a multifunctional receptor protein that is involved in nerve, blood vessel, and tumor development, with implications in immune regulation, tumor growth, and angiogenesis.

参考文献:

1. Gotot J. et al. (2018). Immunol Cell Biol. 96(8):852-862.
2. Yang ZG. et al. (2019). Anat Rec (Hoboken). 302(7):1127-1135.
3. Liu SD. et al. (2020). Chin Med J (Engl). 134(5):508-517.
4. Chaudhary B. et al. (2014). Cancer Immunol Immunother. 63(2):81-99.