Human P53 Antibody Pair Set

背景信息

P53, also known as TP53, belongs to the p53 family, in SDS-PAGE, the observed molecular weight is about 53 kDa. P53 acts as a tumor suppressor in many tumor types, including growth arrest or apoptosis depending on the physiological circumstances and cell types. P53 is activated in response to alteration of normal cell homeostasis, including DNA damage, nutrient starvation, heat shock, virus infection, pH change, hypoxia, and oncogene activation. P53 maintains genetic stability by regulating different processes, such as cell-cycle arrest, DNA synthesis and repair, programmed cell death, and energy metabolism. Activation of p53 can lead to either cell cycle arrest and DNA repair or apoptosis . P53 can be phosphorylated by ATM, ATR, and DNA-PK at Ser15 and Ser37.