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Recombinant Human Thrombomodulin protein (His Tag)

种属

Human

纯度

>90 %, SDS-PAGE

标签

His Tag

生物活性

未测试

Cat no : Eg0944

Print datasheet

Synonyms

THBD, Thrombomodulin, CD141, Fetomodulin, THRM

验证数据展示

  • Purity of Recombinant Human Thrombomodulin was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) conditions and stained using Coomassie blue.

    Purity of Recombinant Human Thrombomodulin was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) conditions and stained using Coomassie blue.

产品信息

纯度 >90 %, SDS-PAGE
内毒素 <0.1 EU/μg protein, LAL method
生物活性 Not tested
来源 HEK293-derived Human Thrombomodulin protein Ala19-Ser515 (Accession# P07204) with a His tag at the C-terminus.
基因ID 7056
蛋白编号 P07204
预测分子量 52.9 kDa
SDS-PAGE 70-100 kDa, reducing (R) conditions
组分 Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization.
复溶 Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water.
储存条件
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
  • Until expiry date, -20℃ to -80℃ as lyophilized proteins.
  • 3 months, -20℃ to -80℃ under sterile conditions after reconstitution.
运输条件 The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature.

背景信息

Thrombomodulin, also known as CD141, is an endothelial cell surface glycoprotein that forms a 1:1 complex with the coagulation factor thrombin and plays an important role as a natural anticoagulant. Thrombomodulin serves to convert thrombin from a procoagulant protein into the activator for protein C. Once converted to activated protein C (APC), this protein serves as a major anticoagulant in blood. Thrombomodulin is also located in other cells (keratinocytes, osteoblasts, macrophages,...) where it might be involved in cell differentiation or in inflammation. Mutations in the gene of thrombomodulin are a cause of thromboembolic disease, also known as inherited thrombophilia.

参考文献:

1. N L Esmon, et al. (1987) Semin Thromb Hemost. 13(4):454-63.
2. A K Ohlin, et al. (1997) Thromb Haemost. 78(1):396-400.
3. M C Boffa, et al. (1998) Lupus.7 Suppl 2:S120-5.
4. Georgia Anastasiou, et al. (2012) Blood Coagul Fibrinolysis. 23(1):1-10.