Recombinant Human VE-cadherin/CD144 protein (His Tag)
种属
Human
纯度
>90 %, SDS-PAGE
标签
His Tag
生物活性
未测试
验证数据展示
产品信息
纯度 | >90 %, SDS-PAGE |
内毒素 | <0.1 EU/μg protein, LAL method |
生物活性 | Not tested |
来源 | HEK293-derived Human VE-cadherin protein Asp48-Gln599 (Accession# P33151-1) with a His tag at the C-terminus. |
基因ID | 1003 |
蛋白编号 | P33151-1 |
预测分子量 | 63.1 kDa |
SDS-PAGE | 70-85 kDa, reducing (R) conditions |
组分 | Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization. |
复溶 | Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water. |
储存条件 |
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
|
运输条件 | The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature. |
背景信息
Vascular endothelial cadherin (VE-cadherin), also known as Cadherin-5 (CDH5) or CD144, is a member of the type II classical cadherin family of cell adhesion proteins. VE-cadherin is expressed specifically in endothelial cells and mediates homophilic adhesion in the vascular endothelium. VE-cadherin plays a role in the organization of lateral endothelial junctions and in the control of permeability properties of vascular endothelium. VE-cadherin has also been shown to be required for angiogenesis.
参考文献:
1. Brasch J. et al. (2011). J Mol Biol. 408(1):57-73. 2. Breier G. et al. (1996). Blood. 87(2):630-41. 3. Wallez Y. et al. (2006). Trends Cardiovasc Med. 16(2):55-9. 4. Vestweber D. (2008). Arterioscler Thromb Vasc Biol. 28(2):223-32.