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  • Featured Product
  • KD/KO Validated

IDE Polyclonal antibody, PBS Only

IDE Polyclonal Antibody for WB, IHC, IP, Indirect ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

WB, IHC, IP, Indirect ELISA

Conjugate

Unconjugated

Cat no : 21728-1-PBS

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Synonyms

验证数据展示

  • WB analysis using 21728-1-AP (same clone as 21728-1-PBS)

    WB analysis using 21728-1-AP (same clone as 21728-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 21728-1-AP (IDE antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 21728-1-PBS in a different storage buffer formulation.

  • IHC staining of human kidney using 21728-1-AP (same clone as 21728-1-PBS)

    IHC staining of human kidney using 21728-1-AP (same clone as 21728-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human kidney using 21728-1-AP (IDE antibody) at dilution of 1:50 (under 10x lens). This data was developed using the same antibody clone with 21728-1-PBS in a different storage buffer formulation.

  • IHC staining of human kidney using 21728-1-AP (same clone as 21728-1-PBS)

    IHC staining of human kidney using 21728-1-AP (same clone as 21728-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human kidney using 21728-1-AP (IDE antibody) at dilution of 1:50 (under 40x lens). This data was developed using the same antibody clone with 21728-1-PBS in a different storage buffer formulation.

  • IP experiment of HepG2 using 21728-1-AP (same clone as 21728-1-PBS)

    IP experiment of HepG2 using 21728-1-AP (same clone as 21728-1-PBS)

    IP result of anti-IDE (IP:21728-1-AP, 4ug; Detection:21728-1-AP 1:500) with HepG2 cells lysate 1600ug. This data was developed using the same antibody clone with 21728-1-PBS in a different storage buffer formulation.

  • WB analysis of HeLa using 21728-1-AP (same clone as 21728-1-PBS)

    WB analysis of HeLa using 21728-1-AP (same clone as 21728-1-PBS)

    WB result of IDE antibody (21728-1-AP; 1:400; incubated at room temperature for 1.5 hours) with sh-Control and sh-IDE transfected HeLa cells. This data was developed using the same antibody clone with 21728-1-PBS in a different storage buffer formulation.

产品信息

21728-1-PBS targets IDE in WB, IHC, IP, Indirect ELISA applications and shows reactivity with human samples.

Tested Applications WB, IHC, IP, Indirect ELISA Application Description
Tested Reactivity human
Immunogen IDE fusion protein Ag16392 种属同源性预测
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Full Name Abeta degrading protease
Synonyms
Calculated Molecular Weight 1019 aa, 118 kDa
Observed Molecular Weight 100-120 kDa
GenBank Accession NumberBC096336
Gene Symbol IDE
Gene ID (NCBI) 3416
RRIDAB_10804773
Conjugate Unconjugated
Form Liquid
Purification MethodAntigen affinity purification
UNIPROT IDP14735
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

IDE (INS-degrading enzyme) belongs to the peptidase M16 family. It is also known as insulysin and is a 110-kD neutral metallopeptidase that can degrade a number of peptides, including INS and beta-amyloid(PMID:9830016). The reduction of IDE expression may be a risk factor for AD, and that IDE may interact with APOE status to affect beta-amyloid metabolism(PMID:12507914). It can exsit as a homodimer and form higher oligomers(PMID:17613531). This antibody is specific to IDE.