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IHCeasy EXOSC10 Ready-To-Use IHC Kit

EXOSC10 Ready-to-use reagent kit for IHC.

Reactivity

Human, Mouse, Rat

Sample Type

FFPE tissue

Cat No : KHC1665

Synonyms

Autoantigen PM/Scl 2, EXOSC10, exosome component 10, p2, p3, p4, PM Scl, PM/Scl 100, PMSCL, PMSCL2, RRP6, Rrp6p

Validation Data Gallery

  • Immunohistochemical analysis of paraffin-embedded human stomach cancer tissue slide using KHC1665 (EXOSC10 IHC Kit).

    Immunohistochemical analysis of paraffin-embedded human stomach cancer tissue slide using KHC1665 (EXOSC10 IHC Kit).

  • Immunohistochemical analysis of paraffin-embedded mouse skin tissue slide using KHC1665 (EXOSC10 IHC Kit).

    Immunohistochemical analysis of paraffin-embedded mouse skin tissue slide using KHC1665 (EXOSC10 IHC Kit).

  • Immunohistochemical analysis of paraffin-embedded rat skin tissue slide using KHC1665 (EXOSC10 IHC Kit).

    Immunohistochemical analysis of paraffin-embedded rat skin tissue slide using KHC1665 (EXOSC10 IHC Kit).

  • Components in IHCeasy ready-to-use IHC kit.

Product Information

KHC1665 is a ready-to-use IHC kit for staining of EXOSC10. The kit provides all reagents, from antigen retrieval to cover slip mounting, that require little to no diluting or handling prior to use. Simply apply the reagents to your sample slide according to the protocol and you're steps away from obtaining high-quality IHC data.

Product name IHCeasy EXOSC10 Ready-To-Use IHC Kit
Sample type FFPE tissue
Assay type Immunohistochemistry
Primary antibody type Rabbit Polyclonal
Secondary antibody type Polymer-HRP-Goat anti-Rabbit
Reactivity Human, Mouse, Rat

Kit components

ComponentSizeConcentration
Antigen Retrieval Buffer100 mL50×
Washing Buffer100 mL ×220×
Blocking Buffer5 mLRTU
Primary Antibody5 mLRTU
Secondary Antibody5 mLRTU
Chromogen Component A0.2 mLRTU
Chromogen Component B4 mLRTU
Signal Enhancer5 mLRTU
Counter Staining Reagent5 mLRTU
Mounting Media5 mLRTU
Datasheet1 Copy
Manual1 Copy

Background Information

About 50% of patients with polymyositis/scleroderma (PM-Scl) overlap syndrome are reported to have autoantibodies to a neuclear/nucleolar particle termed PM-Scl. Exosome component 10 (EXOSC10), also named autoantigen PM/Scl 2, is the 100 kDa antigen component of PM-Scl and is recognized by most sera of PM-Scl paitents. EXOSC10 is strongly enriched in the nucleolus and a small amount has been found in cytoplasm supporting the existence of a nucleolar RNA exosome complex form. As a putative catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity, EXOSC10 participates in a multitude of cellular RNA processing and degradation events.

Properties

Storage Instructions All the reagents are stored at 2-8°C. The kit is stable for 6 months from the date of receipt.
Synonyms Autoantigen PM/Scl 2, EXOSC10, exosome component 10, p2, p3, p4, PM Scl, PM/Scl 100, PMSCL, PMSCL2, RRP6, Rrp6p