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TBK1/IKKε-IN-2

TBK1/IKKε-IN-2 是双重TBK1和IKKε抑制剂。

CAS号

1292310-49-6

分子式

C26H27N5O3

主要靶点

IκB/IKK

仅限科研使用

Cat No : CM04724

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Synonyms

验证数据展示

  • CAS No.: 1292310-49-6

    TBK1/IKKε-IN-2
    CAS#: 1292310-49-6

产品信息

TBK1/IKKε-IN-2 is a dual inhibitor of TBK1 and IKKε.

CAS号 1292310-49-6
分子式 C26H27N5O3
主要靶点 IκB/IKK
主要通路 NF-κB信号通路
分子量 457.52
纯度 98.77%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名

靶点活性

IKKε:3.9 nM (IC50, at 10 μM ATP)|TBK1:0.6 nM (IC50, at 5 μM ATP)

体外活性

TBK1/IKKε-IN-2 (Cmpound #1) inhibits TBK1 biochemical function in Ulight kinase assay at 5 and 250 μM ATP concentration with IC50s of 0.6 and 2.6 nM, rsespectively. TBK1/IKKε-IN-2 inhibits IKKε biochemical function in Ulight kinase assay at 10 μM ATP with an IC50 of 3.9 nM. The IC50 of TBK1/IKKε-IN-2 in the Panc 02.13 proliferation assay is 5 μM[1].

溶解度

DMSO:16.5mg/ml (36.06 Mm),Sonification/heating is recommended.

参考文献

1.Muvaffak A, et al. Evaluating TBK1 as a therapeutic target in cancers with activated IRF3. Mol Cancer Res. 2014 Jul;12(7):1055-66.

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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