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Anti-Mouse IL-1 beta Rabbit Recombinant Antibody, PBS Only

IL-1 beta Uni-rAbTM Recombinant Antibody for FC (Intra)

Host / Isotype

Rabbit / IgG

Reactivity

mouse

Applications

FC (Intra)

Conjugate

Unconjugated

CloneNo.

241364B3

Cat no : 98179-1-PBS

Print datasheet

Synonyms

IL 1beta, Il1b, IL-1,IL1, IL-1 beta,IL 1 beta,IL1beta, Il 1b

验证数据展示

  • FC experiment of mouse peritoneal macrophages using 98179-1-RR (same clone as 98179-1-PBS)

    FC experiment of mouse peritoneal macrophages using 98179-1-RR (same clone as 98179-1-PBS)

    1x10^6 untreated or LPS and Brefeldin A treated mouse peritoneal macrophages were intracellularly stained with 0.25 ug Anti-Mouse IL-1 beta Rabbit Recombinant Antibody (98179-1-RR, Clone: 241364B3) and PE-conjugated Goat Anti-Rabbit IgG. Cells were co-stained with APC anti-Mouse CD11b. Cells were fixed with 4% PFA and permeabilized with Flow Cytometry Perm Buffer (PF00011-C). This data was developed using the same antibody clone with 98179-1-PBS in a different storage buffer formulation.

  • Affinity and Kinetic Characterization of 98179-1-RR

    Affinity and Kinetic Characterization of 98179-1-RR

    Biolayer interferometry (BLl) kinetic assays of 98179-1-RR against Mouse IL-1 beta/IL-1F2 were performed. The affinity constant is 32.5 pM.

产品信息

98179-1-PBS targets IL-1 beta in FC (Intra) applications and shows reactivity with mouse samples.

Tested Applications FC (Intra) Application Description
Tested Reactivity mouse
Immunogen Recombinant protein 种属同源性预测
Host / Isotype Rabbit / IgG
Class Recombinant
Type Antibody
Full Name interleukin 1 beta
Synonyms IL 1beta, Il1b, IL-1,IL1, IL-1 beta,IL 1 beta,IL1beta, Il 1b
Calculated Molecular Weight31kDa
GenBank Accession NumberNM_008361.4
Gene Symbol IL-1 beta
Gene ID (NCBI) 16176
Conjugate Unconjugated
Form Liquid
Purification MethodProtein A purfication
UNIPROT IDP10749
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

Interleukin-1 is a pro-inflammatory cytokine with multiple biological effects. The IL-1 gene family encodes three proteins: IL-1α, IL-1β and their naturally occurring inhibitor Il-1RN. Interleukin 1β(IL-1β), mainly produced by blood monocytes and tissue macrophages, has been implicated in mediating both acute and chronic inflammation. IL-1β is known to be involved in a variety of cellular activities, including cell proliferation, differentiation and apoptosis. IL-1β is emerging as a key mediator of carcinogenesis that characterizes host-environment interactions (PMID: 8630372; PMID: 12401481; PMID: 23704929; PMID: 24618930).