IL-17F Monoclonal antibody, PBS Only
IL-17F Monoclonal Antibody for WB, Indirect ELISA
Host / Isotype
Mouse / IgG1
Reactivity
human, mouse
Applications
WB, Indirect ELISA
Conjugate
Unconjugated
CloneNo.
6H5F10
验证数据展示
产品信息
60245-1-PBS targets IL-17F in WB, Indirect ELISA applications and shows reactivity with human, mouse samples.
Tested Applications | WB, Indirect ELISA Application Description |
Tested Reactivity | human, mouse |
Immunogen | IL-17F fusion protein Ag16310 种属同源性预测 |
Host / Isotype | Mouse / IgG1 |
Class | Monoclonal |
Type | Antibody |
Full Name | interleukin 17F |
Synonyms | Cytokine ML 1, IL 17F, IL17F, IL-17F, interleukin 17F, ML 1, ML1 |
Calculated Molecular Weight | 163 aa, 18 kDa |
Observed Molecular Weight | 37 kDa |
GenBank Accession Number | BC070124 |
Gene Symbol | IL-17F |
Gene ID (NCBI) | 112744 |
Conjugate | Unconjugated |
Form | Liquid |
Purification Method | Protein A purification |
UNIPROT ID | Q96PD4 |
Storage Buffer | PBS Only |
Storage Conditions | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
The interleukin 17 (IL-17) family of cytokines contains 6 structurally related cytokines, IL-17A, IL-17B, IL-17C, IL-17D, IL-17E and IL-17F. IL-17 family plays crucial roles in host defense against microbial organisms and in the development of inflammatory diseases. IL-17A is a pro-inflammatory cytokine that also has the capacity to promote angiogenesis and osteoclastogenesis. IL-17F shares the highest homology with IL-17A and signals via a receptor composed by the IL-17RA and IL-17RC subunits. IL-17A and IL-17F can form IL-17A/A or IL-17F/F homodimers, IL-17A/F heterodimers are also formed. IL-17A and IL-17F, produced by the Th17 CD4(+) T cell lineage, have been linked to a variety of inflammatory and autoimmune conditions. IL-17F levels are elevated in sera and lesional psoriatic skin compared to non-lesional tissue. IL-17F also has been implicated in the development of neutrophilic airway inflammation.