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IL-23 p19 Monoclonal antibody, PBS Only

IL-23 p19 Monoclonal Antibody for IHC, Indirect ELISA

Host / Isotype

Mouse / IgG1

Reactivity

human

Applications

IHC, Indirect ELISA

Conjugate

Unconjugated

CloneNo.

1D5D3

Cat no : 66196-1-PBS

Print datasheet

Synonyms

IL23A, IL-23 subunit alpha, IL 23p19, IL 23A, IL 23 subunit alpha

验证数据展示

  • IHC staining of human stomach cancer using 66196-1-Ig (same clone as 66196-1-PBS)

    IHC staining of human stomach cancer using 66196-1-Ig (same clone as 66196-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human stomach cancer tissue slide using 66196-1-Ig (IL-23A antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 66196-1-PBS in a different storage buffer formulation.

    Ready-to-use IHC kits available with IL23A antibody included
  • IHC staining of human stomach cancer using 66196-1-Ig (same clone as 66196-1-PBS)

    IHC staining of human stomach cancer using 66196-1-Ig (same clone as 66196-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human stomach cancer tissue slide using 66196-1-Ig (IL-23A antibody) at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 66196-1-PBS in a different storage buffer formulation.

    Ready-to-use IHC kits available with IL23A antibody included
Planning an IHC experiment? We recommend our IHCeasy IL23A Ready-To-Use IHC Kit. IL23A primary antibody included.

产品信息

66196-1-PBS targets IL-23 p19 in IHC, Indirect ELISA applications and shows reactivity with human samples.

Tested Applications IHC, Indirect ELISA Application Description
Tested Reactivity human
Immunogen IL-23 p19 fusion protein Ag19406 种属同源性预测
Host / Isotype Mouse / IgG1
Class Monoclonal
Type Antibody
Full Name interleukin 23, alpha subunit p19
Synonyms IL23A, IL-23 subunit alpha, IL 23p19, IL 23A, IL 23 subunit alpha
Calculated Molecular Weight 189 aa, 21 kDa
GenBank Accession NumberBC066268
Gene Symbol IL23A
Gene ID (NCBI) 51561
Conjugate Unconjugated
Form Liquid
Purification MethodProtein G purification
UNIPROT IDQ9NPF7
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

Interleukin 23 (IL-23) is a member of the IL12 cytokine family and composed of two subunits, IL12p40 and IL23p19. It is produced by antigen presenting cells and has been shown to promote the production and survival of a distinct lineage of T-cells called TH17 cells. A functional receptor for IL-23 (the IL-23 receptor) has been identified and is composed of Il-12Rβ1 and IL-23R. IL-23 is expressed chiefly by the macrophages and DCs. The IL-23R is found on memory T cells, NKT cells, macrophages, DCs, and naive T cells upon activation by TGF-βand IL-6. The main biological effects of IL-23 identified initially consist of stimulation of antigen presentation by DCs, T cell differentiation to Th17 cells, and production of interferon-γ (IFN-γ). IL-23 acts also as an end-stage effector cytokine through direct action on macrophages.