验证数据展示
产品信息
22859-1-PBS targets IL-31 in IHC, Indirect ELISA applications and shows reactivity with human samples.
Tested Applications | IHC, Indirect ELISA Application Description |
Tested Reactivity | human |
Immunogen | IL-31 fusion protein Ag18848 种属同源性预测 |
Host / Isotype | Rabbit / IgG |
Class | Polyclonal |
Type | Antibody |
Full Name | interleukin 31 |
Synonyms | |
Calculated Molecular Weight | 164 aa, 18 kDa |
GenBank Accession Number | BC132998 |
Gene Symbol | IL-31 |
Gene ID (NCBI) | 386653 |
RRID | AB_2879179 |
Conjugate | Unconjugated |
Form | Liquid |
Purification Method | Antigen affinity purification |
UNIPROT ID | Q6EBC2 |
Storage Buffer | PBS Only |
Storage Conditions | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
IL-31 mRNA encodes a 164-aa precursor and a predicted 141-aa mature polypeptide, displaying an apparent molecular mass of 24 kDa in its glycosylated form. IL31 is a newly discovered four-helix bundle cytokine and expressed by several types of cells under both normal and disease state, such as activated CD4+T cells, mast cells, monocytes, macrophages, immature and mature monocyte-derived dendritic cells and so on. IL-31 signals through a heterodimeric receptor complex consisting of the IL31 receptor alpha (IL31Rα) and the oncostatin M receptor (OSMR). IL-31 plays a predominant function in the mediation of inflammatory and lymphoma-associated itch. Increased IL-31 expression has been detected in inflamed tissues from patients with atopic dermatitis, bowel diseases, allergic asthma and rhinitis.