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验证数据展示

  • FC experiment of C57BL/6 Th2-polarized splenocytes using 98360-2-RR (same clone as 98360-2-PBS)

    FC experiment of C57BL/6 Th2-polarized splenocytes using 98360-2-RR (same clone as 98360-2-PBS)

    1x10^6 unstimulated or PMA, Ionomycin and Brefeldin A treated C57BL/6 Th2-polarized splenocytes were intracellularly stained with 0.125 ug Anti-Mouse IL-4 Rabbit RecAb (98360-2-RR, Clone: 242736G8) and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were co-stained with APC Anti-Mouse CD4 (GK1.5) (APC-65104, Clone: GK1.5). Cells were fixed with 4% PFA and permeabilized with Flow Cytometry Perm Buffer (PF00011-C). This data was developed using the same antibody clone with 98360-2-PBS in a different storage buffer formulation.

Anti-Mouse IL-4 Rabbit Recombinant Antibody, PBS Only

IL-4 Uni-rAbTM Recombinant Antibody for FC (Intra)
Cat No. 98360-2-PBS

产品说明书

CloneNo. 242736G8

宿主/亚型

Rabbit / IgG

种属反应性

mouse

应用

FC (Intra)

别名

interleukin 4, Il4, Il 4, 242736G8

缓冲液配方:  PBS Only
PBS and Azide
PBS Only
偶联物:  Unconjugated
规格: 

-/ -

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产品信息

98360-2-PBS targets IL-4 in FC (Intra) applications and shows reactivity with mouse samples.

经测试应用 FC (Intra) Application Description
经测试反应性 mouse
免疫原 Recombinant protein 种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Recombinant
产品类型 Antibody
全称 interleukin 4
别名 interleukin 4, Il4, Il 4, 242736G8
GenBank蛋白编号BC027514
基因名称 IL-4
Gene ID (NCBI) 16189
偶联类型 Unconjugated
形式 Liquid
纯化方式Protein A purification
UNIPROT IDP07750
储存缓冲液 PBS only , pH 7.3
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

Interleukin-4 (IL-4), a member of the α-helical cytokine family, is produced by activated CD4+ T cells, basophils, and mast cells. It promotes the proliferation and differentiation of antigen-presenting cells. IL-4 also plays a pivotal role in antibody isotype switching and stimulates the production of IgE. This cytokine has been applied in the treatment of autoimmune disorders like multiple myeloma, cancer, psoriasis, and arthritis. IL-4 has also been extensively applied to inhibit detrimental effect of Th1. It may promote the growth of epithelial tumors by mediating increased proliferation and survival. (PMID: 24489573;3049907;21663408)