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IL-4-inhibitor-1

IL-4-inhibitor-1 是 IL-4 的抑制剂 (EC50 = 1.81 µM)。

CAS号

1332184-63-0

分子式

C18H12FN3O2

主要靶点

IL Receptor

仅限科研使用

Cat No : CM16373

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Synonyms

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  • CAS No.: 1332184-63-0

    IL-4-inhibitor-1
    CAS#: 1332184-63-0

产品信息

IL-4 inhibitor is an inhibitor of IL-4.1It binds to IL-4 with a Kdvalue of 1.8 μM and inhibits IL-4 activity in a cell-based reporter assay (EC50= 1.81 μM). It is selective for IL-4 over IL-13 (EC50= 18.2 μM). IL-4 inhibitor inhibits IL-4-induced STAT6 phosphorylation in THP-1 monocytes (EC50= 3.1 μM), indicating inhibition of the IL-4-JAK1-STAT6 signaling pathway.

CAS号 1332184-63-0
分子式 C18H12FN3O2
主要靶点 IL Receptor
主要通路 免疫与炎症
分子量 321.31
纯度 98.26%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名

靶点活性

IL-4:1.81 µM (EC50)

体外活性

IL-4-inhibitor-1 exhibits functional disruption of type II IL-4 binding in a cellular context and dose-dependent reduces pSTAT-6 levels (EC50 = 3.1 µM)[1].

溶解度

Ethanol:10 mg/mL,DMF:27.0 mg/mL (84.1 mM),DMSO:PBS (pH 7.2) (1:5):0.1 mg/mL,DMSO:27.0 mg/mL (84.1 mM)

参考文献

1.Quinnell, S.P., Leifer, B.S., Nestor, S.T., et al.A small-molecule inhibitor to the cytokine interleukin-4ACS Chem. Biol.15(10)2649-2654(2020)

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