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Mouse IL-6 Polyclonal antibody, PBS Only

IL-6 Polyclonal Antibody for WB, Indirect ELISA

Host / Isotype

Rabbit / IgG

Reactivity

mouse

Applications

WB, Indirect ELISA

Conjugate

Unconjugated

Cat no : 29444-1-PBS

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Synonyms

验证数据展示

  • WB analysis using 29444-1-AP (same clone as 29444-1-PBS)

    WB analysis using 29444-1-AP (same clone as 29444-1-PBS)

    LPS and Brefeldin A treated RAW 264.7 cells were subjected to SDS PAGE followed by western blot with 29444-1-AP (IL-6 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 29444-1-PBS in a different storage buffer formulation.

产品信息

29444-1-PBS targets IL-6 in WB, Indirect ELISA applications and shows reactivity with mouse samples.

Tested Applications WB, Indirect ELISA Application Description
Tested Reactivity mouse
Immunogen Recombinant protein 种属同源性预测
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Full Name interleukin 6
Synonyms
Calculated Molecular Weight 24 kDa
Observed Molecular Weight24 kDa
GenBank Accession NumberNM_031168
Gene Symbol Il6
Gene ID (NCBI) 16193
Conjugate Unconjugated
Form Liquid
Purification MethodAntigen affinity purification
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

Interleukin-6 (IL-6) is an interleukin that acts as both a pro-inflammatory and anti-inflammatory cytokine. IL-6 protein is secreted by a variety of cell types including T cells and macrophages as phosphorylated and variably glycosylated molecule. IL-6 plays an essential role in the final differentiation of B-cells into Ig-secreting cells involved in lymphocyte and monocyte differentiation. It induces myeloma and plasmacytoma growth and induces nerve cells differentiation Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. IL-6 is also considered a myokine, a cytokine produced from muscle, and is elevated in response to muscle contraction. IL-6 has been shown to interact with interleukin-6 receptor and glycoprotein 130. Additionally, IL-6 is involved in hematopoiesis, bone metabolism, and cancer progression, and has been defined an essential role in directing transition from innate to acquired immunity.