IL-17A Polyclonal antibody

IL-17A Polyclonal Antibody for IHC, ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

IHC, ELISA and More (3)

Conjugate

Unconjugated

Cat no : 13082-1-AP

Print datasheet

Synonyms

CTLA 8, CTLA8, IL 17, IL 17A, IL17, IL-17, IL17A, interleukin 17A



经过测试的应用

Positive IHC detected inhuman colon cancer tissue, human cervical cancer tissue, human stomach cancer tissue, human colon tissue
Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0

推荐稀释比

ApplicationDilution
Immunohistochemistry (IHC)IHC : 1:50-1:500
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

产品信息

13082-1-AP targets IL-17A in WB, IHC, IF, ELISA, Cell treatment applications and shows reactivity with human samples.

Tested Applications IHC, ELISA Application Description
Cited ApplicationsWB, IHC, IF, Cell treatment
Tested Reactivity human
Cited Reactivityhuman
Immunogen IL-17A fusion protein Ag3733 种属同源性预测
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Full Name interleukin 17A
Synonyms CTLA 8, CTLA8, IL 17, IL 17A, IL17, IL-17, IL17A, interleukin 17A
Calculated Molecular Weight 155 aa, 18 kDa
GenBank Accession NumberBC067505
Gene Symbol IL-17A
Gene ID (NCBI) 3605
ENSEMBL Gene IDENSG00000112115
RRIDAB_10644322
Conjugate Unconjugated
Form Liquid
Purification MethodAntigen affinity purification
UNIPROT IDQ16552
Storage Buffer PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage ConditionsStore at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.

背景介绍

IL17A, also named as IL-17, is a proinflammatory cytokine. IL-17, synthesized only by memory T cells and natural killer cells, has pleiotropic effects, mainly in the recruitment and activation of neutrophils. This cytokine regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis. The IL-17 receptor is a type I transmembrane protein, that is widely expressed on epithelial cells, fibroblasts, B and T cells, and monocytic cells. In psoriatic skin lesions, both Th17 cells and their downstream effector molecules, e.g. IL-17 and IL-22, are highly increased. This antibody got 32-35 kDa band in western blot, maybe due to homodimer formation and differential glycosylations.

实验方案

Product Specific Protocols
IHC protocol for IL-17A antibody 13082-1-APDownload protocol
Standard Protocols
Click here to view our Standard Protocols

发表文章

SpeciesApplicationTitle
WB

Int J Biol Macromol

Chitosan-modified dihydromyricetin liposomes promote the repair of liver injury in mice suffering from diabetes mellitus

Authors - Qiteng Ding
humanIF

J Autoimmun

IL-17 is expressed on beta and alpha cells of donors with type 1 and type 2 diabetes.

Authors - Sakthi Rajendran
WB

J Med Chem

Discovery of Orally Available Retinoic Acid Receptor-Related Orphan Receptor γ-t/Dihydroorotate Dehydrogenase Dual Inhibitors for the Treatment of Refractory Inflammatory Bowel Disease.

Authors - Ji-An Chen
IHC

J Invest Dermatol

Reduced Il17a expression distinguishes a Ly6c(lo)MHCII(hi) macrophage population promoting wound healing.

Authors - Rodero Mathieu P MP
IF

Arch Oral Biol

Age-related changes of CD4+ T cell migration and cytokine expression in germ-free and SPF mice periodontium.

Authors - Koichiro Irie
WB

Cell Physiol Biochem

Histone Acetyltransferase Mof Affects the Progression of DSS-Induced Colitis.

Authors - Yang Yang