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  • Featured Product
  • KD/KO Validated

IMPDH2 Monoclonal antibody, PBS Only

IMPDH2 Monoclonal Antibody for WB, IHC, IF/ICC, Indirect ELISA

Host / Isotype

Mouse / IgG1

Reactivity

Human, mouse, rat

Applications

WB, IHC, IF/ICC, Indirect ELISA

Conjugate

Unconjugated

CloneNo.

1B1G8

Cat no : 67663-1-PBS

Print datasheet

Synonyms

IMP dehydrogenase 2, IMPD 2, IMPD2, IMPDH 2, IMPDH II, IMPDH2

验证数据展示

  • WB analysis using 67663-1-Ig (same clone as 67663-1-PBS)

    WB analysis using 67663-1-Ig (same clone as 67663-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 67663-1-Ig (IMPDH2 antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. The membrane was stripped and reblotted with HRP-conjugated GAPDH Monoclonal antibody (HRP-60004) as loading control. This data was developed using the same antibody clone with 67663-1-PBS in a different storage buffer formulation.

  • IHC staining of human breast hyperplasia using 67663-1-Ig (same clone as 67663-1-PBS)

    IHC staining of human breast hyperplasia using 67663-1-Ig (same clone as 67663-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human breast hyperplasia tissue slide using 67663-1-Ig (IMPDH2 antibody) at dilution of 1:1000 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 67663-1-PBS in a different storage buffer formulation.

  • IF Staining of A549 using 67663-1-Ig (same clone as 67663-1-PBS)

    IF Staining of A549 using 67663-1-Ig (same clone as 67663-1-PBS)

    Immunofluorescent analysis of (-20°C Ethanol) fixed A549 cells using IMPDH2 antibody (67663-1-Ig, Clone: 1B1G8 ) at dilution of 1:400 and CoraLite®488-Conjugated Goat Anti-Mouse IgG(H+L). This data was developed using the same antibody clone with 67663-1-PBS in a different storage buffer formulation.

  • WB analysis of A549 using 67663-1-Ig (same clone as 67663-1-PBS)

    WB analysis of A549 using 67663-1-Ig (same clone as 67663-1-PBS)

    WB result of IMPDH2 antibody (67663-1-Ig; 1:40000; incubated at room temperature for 1.5 hours) with sh-Control and sh-IMPDH2 transfected A549 cells. This data was developed using the same antibody clone with 67663-1-PBS in a different storage buffer formulation.

产品信息

67663-1-PBS targets IMPDH2 in WB, IHC, IF/ICC, Indirect ELISA applications and shows reactivity with Human, mouse, rat samples.

Tested Applications WB, IHC, IF/ICC, Indirect ELISA Application Description
Tested Reactivity Human, mouse, rat
Immunogen IMPDH2 fusion protein Ag17170 种属同源性预测
Host / Isotype Mouse / IgG1
Class Monoclonal
Type Antibody
Full Name IMP (inosine monophosphate) dehydrogenase 2
Synonyms IMP dehydrogenase 2, IMPD 2, IMPD2, IMPDH 2, IMPDH II, IMPDH2
Calculated Molecular Weight 514 aa, 56 kDa
Observed Molecular Weight 56 kDa
GenBank Accession NumberBC012840
Gene Symbol IMPDH2
Gene ID (NCBI) 3615
RRIDAB_2882860
Conjugate Unconjugated
Form Liquid
Purification MethodProtein A purification
UNIPROT IDP12268
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

IMPDH2, also named as IMPD2, belongs to the IMPDH/GMPR family. It is a rate limiting enzyme in the de novo synthesis of guanine nucleotides and therefore is involved in the regulation of cell growth. It may also have a role in the development of malignancy and the growth progression of some tumors. IMPDH2 is a key enzyme in the purine nucleotide biosynthetic pathway and constitutes a pivotal biological target for immunosuppressant and antiviral drugs. (PMID:21181270)