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IRAK4-IN-4

IRAK4-IN-4 是白介素-1 受体相关激酶抑制剂，IC50为 2.8 nM。它还抑制环 GMP-AM 合酶 ，IC50为 2.1 nM。详细信息请参考专利文献 CN107163044A 中的化合物 15。

CAS号

1850276-58-2

分子式

C22H16N2O2

主要靶点

IRAK|cGAS

仅限科研使用

Cat No : CM04853

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Synonyms

验证数据展示

  • CAS No.: 1850276-58-2

    IRAK4-IN-4
    CAS#: 1850276-58-2

产品信息

IRAK4-IN-4 inhibits cyclic GMP-AMP synthase (cGAS) with an IC50 of 2.1 nM.IRAK4-IN-4 is an interleukin-1 receptor–associated kinase 4 (IRAK4) inhibitor, has an IC50 of 2.8 nM.

CAS号 1850276-58-2
分子式 C22H16N2O2
主要靶点 IRAK|cGAS
主要通路 NF-κB信号通路|免疫与炎症
分子量 340.37
纯度 99.13%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名

靶点活性

cGAS:2.1 nM (IC50)|IRAK4:2.8 nM (IC50)

溶解度

DMSO:24 mg/mL(70.51 mM)

参考文献

1.One class has the naphthalene second dione compounds and its derivative of protease modification activities. CN107163044A.

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