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Host
0
Species Reactivity
0
Species Reactivity
0
Conjugate
0
Conjugate
0
Compatible Species
0
Conjugate
0

验证数据展示

  • WB analysis using 67142-1-Ig (same clone as 67142-1-PBS)

    WB analysis using 67142-1-Ig (same clone as 67142-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 67142-1-Ig (IRF8 antibody) at dilution of 1:3000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 67142-1-PBS in a different storage buffer formulation.

  • IF Staining of THP-1 using 67142-1-Ig (same clone as 67142-1-PBS)

    IF Staining of THP-1 using 67142-1-Ig (same clone as 67142-1-PBS)

    Immunofluorescent analysis of (4% PFA) fixed THP-1 cells using IRF8 antibody (67142-1-Ig, Clone: 3A10A4 ) at dilution of 1:800 and CoraLite®488-Conjugated Goat Anti-Mouse IgG(H+L). This data was developed using the same antibody clone with 67142-1-PBS in a different storage buffer formulation.

IRF8 Monoclonal antibody, PBS Only

IRF8 Monoclonal Antibody for WB, IF/ICC, ELISA
Cat No. 67142-1-PBS
CloneNo. 3A10A4

Host / Isotype

Mouse / IgG2b

Reactivity

Human

Applications

WB, IF/ICC, ELISA

Synonyms

H ICSBP, ICSBP, ICSBP1, interferon regulatory factor 8, IRF 8, IRF8

Formulation:  PBS and Azide
PBS and Azide
Conjugate:  Unconjugated
Size: 

-/ -

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产品信息

67142-1-PBS targets IRF8 in WB, IF/ICC, ELISA applications and shows reactivity with Human samples.

Tested Applications WB, IF/ICC, ELISA Application Description
Tested Reactivity Human
Immunogen IRF8 fusion protein Ag19909 种属同源性预测
Host / Isotype Mouse / IgG2b
Class Monoclonal
Type Antibody
Full Name ICSBP1
Synonyms H ICSBP, ICSBP, ICSBP1, interferon regulatory factor 8, IRF 8, IRF8
Calculated Molecular Weight 426 aa, 48 kDa
Observed Molecular Weight 48 kDa
GenBank Accession NumberBC126247
Gene Symbol IRF8
Gene ID (NCBI) 3394
RRIDAB_2882441
Conjugate Unconjugated
Form Liquid
Purification MethodProtein A purification
UNIPROT IDQ02556
Storage Buffer PBS only
Storage ConditionsStore at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

IRF8 also named as ICSBP1, is a transcription factor of the IFN regulatory factor (IRF) family. The IRF family proteins bind to the IFN-stimulated response element (ISRE) and regulate expression of genes stimulated by type I IFNs, namely IFN-alpha and IFN-beta. IRF family proteins also control expression of IFN-alpha and IFN-beta-regulated genes that are induced by viral infection. IRF8 specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (the IFN consensus sequence (ICS)). It plays a negative regulatory role in cells of the immune system. It is predominantly in lymphoid tissues.