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ISO-1

ISO-1 (MIF Antagonist) 是一种巨噬细胞移动抑制因子(MIF) 拮抗剂(IC50:7 μM)。

CAS号

478336-92-4

分子式

C12H13NO4

主要靶点

Others

仅限科研使用

Cat No : CM05554

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Synonyms

MIF Antagonist|ISO 1

验证数据展示

  • CAS No.: 478336-92-4

    ISO-1
    CAS#: 478336-92-4

产品信息

ISO-1 (MIF Antagonist) is an inhibitor of the dopachrome tautomerase activity, blocks the activation of NF-κB and TNF-α secretion from LPS-treated macrophages.

CAS号 478336-92-4
分子式 C12H13NO4
主要靶点 Others
主要通路 其他
分子量 235.2
纯度 98.56%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名 MIF Antagonist|ISO 1

靶点活性

MIF:7 μM

溶解度

DMSO:23.5 mg/mL(100 mM)

参考文献

1.Xu L, et al. Drug Discov Today. 2013 Jun;18(11-12):592-600.
2.Lubetsky JB, et al. J Biol Chem. 2002 Jul 12;277(28):24976-82.
3.Al-Abed Y, et al. J Biol Chem. 2005 Nov 4;280(44):36541-4.
4.Dagia NM, et al. Eur J Pharmacol. 2009 Apr 1;607(1-3):201-12.
5.Li S, Nie K, Zhang Q, et al. Macrophage Migration Inhibitory Factor Mediates Neuroprotective Effects by Regulating Inflammation, Apoptosis and Autophagy in Parkinson's Disease[J]. Neuroscience. 2019.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
×
=
×
C1   V1   C2   V2