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(E/Z)-IT-603

(E/Z)-IT-603 是一种c-Rel 抑制剂，其IC50=3 μM。它是 E-IT-603 和 Z-IT-603的混合物。它具有抗癌作用。它有望作为调节剂调节移植物抗宿主病和恶性病中的 T 细胞反应。

CAS号

292168-90-2

分子式

C11H9BrN2O3S

主要靶点

NF-κB|Others

仅限科研使用

Cat No : CM05268

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Synonyms

IT603

验证数据展示

  • CAS No.: 292168-90-2

    (E/Z)-IT-603
    CAS#: 292168-90-2

产品信息

(E/Z)-IT-603 is a cell-permeable c-Rel inhibitor (IC50: 3μM). IT-603 directly and reversibly binds to c-Rel to change its conformation and blocks its DNA binding and transcriptional activity.

CAS号 292168-90-2
分子式 C11H9BrN2O3S
主要靶点 NF-κB|Others
主要通路 NF-κB信号通路|其他
分子量 329.17
纯度 98.97%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名 IT603

溶解度

DMSO:27.5 mg/mL (83.54 mM)

参考文献

1.Shono Y , Tuckett A Z , Ouk S , et al. A Small-Molecule c-Rel Inhibitor Reduces Alloactivation of T Cells without Compromising Antitumor Activity[J]. Cancer Discovery, 2014, 4(5):578-91.

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