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验证数据展示

  • IHC staining of human colon using 13601-1-AP (same clone as 13601-1-PBS)

    IHC staining of human colon using 13601-1-AP (same clone as 13601-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human colon tissue slide using 13601-1-AP (ITM2C antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 13601-1-PBS in a different storage buffer formulation.

ITM2C Polyclonal antibody, PBS Only

ITM2C Polyclonal Antibody for IHC, Indirect ELISA
Cat No. 13601-1-PBS

产品说明书

宿主/亚型

Rabbit / IgG

种属反应性

human

应用

IHC, Indirect ELISA

别名

缓冲液配方:  PBS Only
PBS and Azide
PBS Only
偶联物:  Unconjugated
规格: 

-/ -

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产品信息

13601-1-PBS targets ITM2C in IHC, Indirect ELISA applications and shows reactivity with human samples.

经测试应用 IHC, Indirect ELISA Application Description
经测试反应性 human
免疫原 ITM2C fusion protein Ag3876 种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Polyclonal
产品类型 Antibody
全称 integral membrane protein 2C
别名
计算分子量230aa,26 kDa; 267aa,30 kDa
观测分子量 30 kDa
GenBank蛋白编号BC025742
基因名称 ITM2C
Gene ID (NCBI) 81618
RRIDAB_2877960
偶联类型 Unconjugated
形式 Liquid
纯化方式Antigen affinity purification
UNIPROT IDQ9NQX7
储存缓冲液 PBS only , pH 7.3
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

The Integral membrane protein 2C (ITM2C) is a type II integral transmembrane protein belonging to a family composed of at least two other members, ITM2A and ITM2B. ITM2C, often called transmembrane protein BRI3, is highly expressed in brain tissue. Yeast two-hybrid screen system revealed that BRI3 could interact with beta-secretase beta-amyloid protein converting enzyme (BACE)1 and the microtubule-destabilizing protein SCG10 (STMN2). It may play a role in TNF-induced cell death and neuronal differentiation. BRI3 was found to inhibit the various processing of amyloid precursor protein (APP) by blocking the access of alpha- and beta-secretases to APP, competitive inhibition of APP processing by BRI3 may provide a new approach to Alzheimer disease (AD) therapy and prevention.