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ITM2C Monoclonal antibody, PBS Only

ITM2C Monoclonal Antibody for IF/ICC, Indirect ELISA

Host / Isotype

Mouse / IgG2a

Reactivity

human

Applications

IF/ICC, Indirect ELISA

Conjugate

Unconjugated

CloneNo.

2E8G11

Cat no : 60095-1-PBS

Print datasheet

Synonyms

BRICD2C, Cerebral protein 14, E25, E25C, integral membrane protein 2C, ITM2C, ITM3, PSEC0047, Transmembrane protein BRI3

验证数据展示

  • IF Staining of HepG2 using 60095-1-Ig (same clone as 60095-1-PBS)

    IF Staining of HepG2 using 60095-1-Ig (same clone as 60095-1-PBS)

    Immunofluorescent analysis of HepG2 cells using 60095-1-Ig (ITM2C antibody) at dilution of 1:50 and Rhodamine-Goat anti-Mouse IgG. This data was developed using the same antibody clone with 60095-1-PBS in a different storage buffer formulation.

产品信息

60095-1-PBS targets ITM2C in IF/ICC, Indirect ELISA applications and shows reactivity with human samples.

Tested Applications IF/ICC, Indirect ELISA Application Description
Tested Reactivity human
Immunogen ITM2C fusion protein Ag4409 种属同源性预测
Host / Isotype Mouse / IgG2a
Class Monoclonal
Type Antibody
Full Name integral membrane protein 2C
Synonyms BRICD2C, Cerebral protein 14, E25, E25C, integral membrane protein 2C, ITM2C, ITM3, PSEC0047, Transmembrane protein BRI3
Calculated Molecular Weight230aa,26 kDa; 267aa,30 kDa
Observed Molecular Weight 35 kDa
GenBank Accession NumberBC025742
Gene Symbol ITM2C
Gene ID (NCBI) 81618
RRIDAB_2296429
Conjugate Unconjugated
Form Liquid
Purification MethodProtein A purification
UNIPROT IDQ9NQX7
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

The Integral membrane protein 2C (ITM2C) is a type II integral transmembrane protein belonging to a family composed of at least two other members, ITM2A and ITM2B. ITM2C, often called transmembrane protein BRI3, is highly expressed in brain tissue. Yeast two-hybrid screen system revealed that BRI3 could interact with beta-secretase beta-amyloid protein converting enzyme (BACE)1 and the microtubule-destabilizing protein SCG10 (STMN2). It may play a role in TNF-induced cell death and neuronal differentiation. BRI3 was found to inhibit the various processing of amyloid precursor protein (APP) by blocking the access of alpha- and beta-secretases to APP, competitive inhibition of APP processing by BRI3 may provide a new approach to Alzheimer disease (AD) therapy and prevention.