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Isobavachalcone

Isobavachalcone (Corylifolinin) 是来源于补骨脂的一种Akt 信号通路抑制剂，可诱导人类癌细胞凋亡，以IC50值为 7.92 μM 抑制 OVCAR-8 癌细胞生长，具有抗癌和抗增殖活性。它还能诱导 OVCAR-8 细胞中活性氧的产生。

CAS号

20784-50-3

分子式

C20H20O4

主要靶点

Apoptosis|Akt|Reactive Oxygen Species|Others|Autophagy

仅限科研使用

Cat No : CM00908

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Synonyms

Corylifolinin|Isobacachalcone|补骨脂乙素

验证数据展示

  • CAS No.: 20784-50-3

    Isobavachalcone
    CAS#: 20784-50-3

产品信息

Isobavachalcone is a chalcone constituent of Angelica keiskei, has potent anti-inflammatory activity, possible can ameliorate neuronal injury in brain diseases associated with inflammation.

CAS号 20784-50-3
分子式 C20H20O4
主要靶点 Apoptosis|Akt|Reactive Oxygen Species|Others|Autophagy
主要通路 凋亡|免疫与炎症|PI3K/Akt/mTOR信号通路|自噬|NF-κB信号通路|细胞骨架|其他|代谢
分子量 324.38
纯度 99.55%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名 Corylifolinin|Isobacachalcone|补骨脂乙素

靶点活性

OVCAR-8 cell:7.92 μM (IC50)

溶解度

DMSO:58 mg/mL(178.8 mM),Chloroform, Dichloromethane, Ethyl Acetate, Acetone:Soluble

参考文献

1.Lee KM,et al. Isobavachalcone attenuates lipopolysaccharide-induced ICAM-1 expression in brain endothelial cells through blockade of toll-like receptor 4 signaling pathways. Eur J Pharmacol. 2015 May 5;754:11-8.

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