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Host
0
Species Reactivity
0
Species Reactivity
0
Conjugate
0
Conjugate
0
Compatible Species
0
Conjugate
0

验证数据展示

  • WB analysis using 12933-1-AP (same clone as 12933-1-PBS)

    WB analysis using 12933-1-AP (same clone as 12933-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 12933-1-AP (KCNMB1 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 12933-1-PBS in a different storage buffer formulation.

KCNMB1 Polyclonal antibody, PBS Only

KCNMB1 Polyclonal Antibody for WB, Indirect ELISA
Cat No. 12933-1-PBS

Print datasheet

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse, rat

Applications

WB, Indirect ELISA

Synonyms

Calcium-activated potassium channel subunit beta-1, Calcium-activated potassium channel subunit beta, BKbeta1, BKbeta, BK channel subunit beta-1

Formulation:  PBS Only
PBS and Azide
PBS Only
Conjugate:  Unconjugated
Size: 

-/ -

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产品信息

12933-1-PBS targets KCNMB1 in WB, Indirect ELISA applications and shows reactivity with human, mouse, rat samples.

Tested Applications WB, Indirect ELISA Application Description
Tested Reactivity human, mouse, rat
Immunogen KCNMB1 fusion protein Ag3888 种属同源性预测
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Full Name potassium large conductance calcium-activated channel, subfamily M, beta member 1
Synonyms Calcium-activated potassium channel subunit beta-1, Calcium-activated potassium channel subunit beta, BKbeta1, BKbeta, BK channel subunit beta-1
Calculated Molecular Weight130aa,15 kDa; 190aa,22 kDa
Observed Molecular Weight 31 kDa
GenBank Accession NumberBC025707
Gene Symbol KCNMB1
Gene ID (NCBI) 3779
Conjugate Unconjugated
Form Liquid
Purification MethodAntigen affinity purification
UNIPROT IDQ16558
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

Calcium-activated potassium channel subunit beta-1 is a protein encoded by KCNMB1 gene, also named as BK beta1, slo beta1. MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the pore-forming alpha subunit and the product of this gene, the modulatory beta subunit. Intracellular calcium regulates the physical association between the alpha and beta subunits. Beta subunits (beta 1-4) are highly tissue specific in their expression, with beta-1 being present predominantly on vascular smooth muscle. Endothelial cells are not known to express beta1, subunits. Beta1, is also known to be expressed in urinary bladder and in some regions of the brain. Association of the beta-1 subunit with the BK channel increases the apparent Ca2+ sensitivity of the channel and decreases voltage dependence.PMID 25015960