- Featured Product
- KD/KO Validated
KCNN4 Polyclonal antibody
KCNN4 Polyclonal Antibody for WB, IF/ICC, ELISA
Host / Isotype
Rabbit / IgG
Reactivity
human and More (2)
Applications
WB, IF/ICC, ELISA and More (2)
Conjugate
Unconjugated
验证数据展示
经过测试的应用
| Positive WB detected in | A431 cells, HepG2 cells, HEK-293 cells |
| Positive IF/ICC detected in | HEK-293 cells |
Planning an IF experiment? We recommend our CoraLite® Plus 488 conjugated versions of this antibody.
推荐稀释比
| Application | Dilution |
|---|---|
| Western Blot (WB) | WB : 1:1000-1:8000 |
| Immunofluorescence (IF)/ICC | IF/ICC : 1:200-1:800 |
| It is recommended that this reagent should be titrated in each testing system to obtain optimal results. | |
| Sample-dependent, Check data in validation data gallery. | |
产品信息
23271-1-AP targets KCNN4 in WB, IHC, IF/ICC, ELISA applications and shows reactivity with human samples.
| Tested Applications | WB, IF/ICC, ELISA Application Description |
| Cited Applications | WB, IHC, IF |
| Tested Reactivity | human |
| Cited Reactivity | human, mouse, canine |
| Immunogen | KCNN4 fusion protein Ag19774 种属同源性预测 |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Full Name | potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4 |
| Synonyms | KCa3.1, Intermediate conductance calcium-activated potassium channel protein 4, IKCA1, IK1, hSK4 |
| Calculated Molecular Weight | 427 aa, 48 kDa |
| Observed Molecular Weight | 48 kDa |
| GenBank Accession Number | BC015337 |
| Gene Symbol | KCNN4 |
| Gene ID (NCBI) | 3783 |
| RRID | AB_2879243 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification Method | Antigen Affinity purified |
| UNIPROT ID | O15554 |
| Storage Buffer | PBS with 0.02% sodium azide and 50% glycerol pH 7.3. |
| Storage Conditions | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. |
背景介绍
The intermediate conductance calcium-activated potassium channel KCNN4, also known as KCa3.1, IK1, or SK4, is a member of the potassium channel KCNN family. KCNN4 is expressed in T cells, mast cells, macrophages, erythrocytes, vascular smooth muscle cells, airway smooth muscle cells, intestinal and airway epithelial cells (PMID: 19681865; 21493782). Functionally, KCNN4 plays a key role in calcium-dependent cell functions, such as proliferation, activation, and migration, in a broad range of cell types (PMID: 21493782).
实验方案
| Product Specific Protocols | |
|---|---|
| WB protocol for KCNN4 antibody 23271-1-AP | Download protocol |
| IF protocol for KCNN4 antibody 23271-1-AP | Download protocol |
| Standard Protocols | |
|---|---|
| Click here to view our Standard Protocols |
发表文章
| Species | Application | Title |
|---|---|---|
Cancer Cell Int KCNN4 may weaken anti-tumor immune response via raising Tregs and diminishing resting mast cells in clear cell renal cell carcinoma. | ||
Cancer Biomark KCNN4 promotes the progression of lung adenocarcinoma by activating the AKT and ERK signaling pathways
| ||
Front Physiol New KCNN4 Variants Associated With Anemia: Stomatocytosis Without Erythrocyte Dehydration | ||
Cardiovasc Ther KCa3.1 Promotes Proinflammatory Exosome Secretion by Activating AKT/Rab27a in Atrial Myocytes during Rapid Pacing | ||
Biochem Biophys Res Commun Integrated expression profiling of potassium channels identifys KCNN4 as a prognostic biomarker of pancreatic cancer. | ||
Nat Commun Phospholipid scrambling induced by an ion channel/metabolite transporter complex |
