Kamebakaurin

Kamebakaurin (Kamebakaurine) 是一种提取自Isodon japonicus 中的天然产物,是一种NF-κB 的抑制剂,能够抑制 p50 的 DNA 结合活性。

CAS号

73981-34-7

分子式

C20H30O5

主要靶点

NF-κB

仅限科研使用

Cat No : CM12880

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Synonyms

Kamebakaurine|尾叶香茶菜丙素



产品信息

1. Kamebakaurin has the ability to protect the liver from APAP-induced hepatotoxicity, presumably by both inhibiting the inflammatory response and oxidative stress. 2. Kamebakaurin inhibits the expression of hypoxia-inducible factor-1α and its target genes to confer antitumor activity. 3. Kamebakaurin has anti-cancer and anti-inflammatory activities through direct inhibition of DNA-binding activity of nuclear factor-kappa B (NF-κB) p50.4. Kamebakaurin has anti-neuroinflammatory activity via inhibition of c-Jun NH -terminal kinase and p38 mitogen-activated protein kinase pathway in activated microglial cells.

CAS号 73981-34-7
分子式 C20H30O5
主要靶点 NF-κB
主要通路 NF-κB信号通路
分子量 350.45
纯度 98.05%, 此纯度可做参考,具体纯度与批次有关系,可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名 Kamebakaurine|尾叶香茶菜丙素

溶解度

DMSO:Soluble,Chloroform, Dichloromethane, Ethyl Acetate, Acetone, etc.:Soluble

参考文献

1.Wang K S , Lee J J . Kamebakaurin inhibits the expression of hypoxia-inducible factor-1α and its target genes to confer antitumor activity[J]. Oncology Reports, 2016, 35(4):2045.

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