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验证数据展示

  • WB analysis using 21774-1-AP (same clone as 21774-1-PBS)

    WB analysis using 21774-1-AP (same clone as 21774-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 21774-1-AP (CACNA1C antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 21774-1-PBS in a different storage buffer formulation.

  • IHC staining of mouse brain using 21774-1-AP (same clone as 21774-1-PBS)

    IHC staining of mouse brain using 21774-1-AP (same clone as 21774-1-PBS)

    Immunohistochemical analysis of paraffin-embedded mouse brain tissue slide using 21774-1-AP (L-VOCC antibody) at dilution of 1:400 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 21774-1-PBS in a different storage buffer formulation.

  • IHC staining of mouse brain using 21774-1-AP (same clone as 21774-1-PBS)

    IHC staining of mouse brain using 21774-1-AP (same clone as 21774-1-PBS)

    Immunohistochemical analysis of paraffin-embedded mouse brain tissue slide using 21774-1-AP (L-VOCC antibody) at dilution of 1:400 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 21774-1-PBS in a different storage buffer formulation.

  • IF Staining of mouse brain using 21774-1-AP (same clone as 21774-1-PBS)

    IF Staining of mouse brain using 21774-1-AP (same clone as 21774-1-PBS)

    Immunofluorescent analysis of (4% PFA) fixed mouse brain tissue using L-VOCC antibody (21774-1-AP) at dilution of 1:200 and CoraLite®488-Conjugated AffiniPure Goat Anti-Rabbit IgG(H+L). This data was developed using the same antibody clone with 21774-1-PBS in a different storage buffer formulation.

  • IF Staining of mouse brain using 21774-1-AP (same clone as 21774-1-PBS)

    IF Staining of mouse brain using 21774-1-AP (same clone as 21774-1-PBS)

    Immunofluorescent analysis of (4% PFA) fixed mouse brain tissue using L-VOCC antibody (21774-1-AP) at dilution of 1:200 and CoraLite®488-Conjugated AffiniPure Goat Anti-Rabbit IgG(H+L). This data was developed using the same antibody clone with 21774-1-PBS in a different storage buffer formulation.

  • FC experiment of HeLa using 21774-1-AP (same clone as 21774-1-PBS)

    FC experiment of HeLa using 21774-1-AP (same clone as 21774-1-PBS)

    1X10^6 HeLa cells were intracellularly stained with 0.4 ug Anti-Human L-VOCC (21774-1-AP) and CoraLite®488-Conjugated AffiniPure Goat Anti-Rabbit IgG(H+L) at dilution 1:1000 (red), or 0.4 ug Isotype Control. Cells were fixed with 4% PFA and permeabilized with Flow Cytometry Perm Buffer (PF00011-C). This data was developed using the same antibody clone with 21774-1-PBS in a different storage buffer formulation.

CACNA1C Polyclonal antibody, PBS Only

CACNA1C Polyclonal Antibody for WB, IHC, IF-P, FC (Intra), Indirect ELISA
Cat No. 21774-1-PBS

产品说明书

宿主/亚型

Rabbit / IgG

种属反应性

human, mouse, rat

应用

WB, IHC, IF-P, FC (Intra), Indirect ELISA

别名

CACH2, CACN2, CACNL1A1, Calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle, CCHL1A1

缓冲液配方:  PBS Only
PBS and Azide
PBS Only
偶联物:  Unconjugated
规格: 

-/ -

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产品信息

21774-1-PBS targets CACNA1C in WB, IHC, IF-P, FC (Intra), Indirect ELISA applications and shows reactivity with human, mouse, rat samples.

经测试应用 WB, IHC, IF-P, FC (Intra), Indirect ELISA Application Description
经测试反应性 human, mouse, rat
免疫原 CACNA1C fusion protein Ag16455 种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Polyclonal
产品类型 Antibody
全称 calcium channel, voltage-dependent, L type, alpha 1C subunit
别名 CACH2, CACN2, CACNL1A1, Calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle, CCHL1A1
计算分子量249 kDa
观测分子量200 kDa
GenBank蛋白编号BC146846
基因名称 CACNA1C
Gene ID (NCBI) 775
RRIDAB_2878918
偶联类型 Unconjugated
形式 Liquid
纯化方式Antigen affinity purification
UNIPROT IDQ13936
储存缓冲液 PBS only , pH 7.3
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

Calcium voltage-gated channel subunit alpha1 C (CACNA1C, also known as CACH2 and Cav1.2) couples transient activation of inward calcium current to transcriptional regulation and plays an important role in dendritic development, neuronal survival, synaptic plasticity, memory formation, learning, and behavior (PMID: 21248242;  16251435; 20169575; 19047462; 18174367). Genetic variation in CACNA1C has also been associated with depression, schizophrenia, and autism spectrum disorders, as well as changes in brain function and structure in control subjects who have no diagnosable psychiatric illness (PMID: 22705413).