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L1CAM Recombinant antibody, PBS Only

L1CAM Uni-rAbTM Recombinant Antibody for IF/ICC, Indirect ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

IF/ICC, Indirect ELISA

Conjugate

Unconjugated

CloneNo.

240978A7

Cat no : 84034-5-PBS

Print datasheet

Synonyms

L1 cell adhesion molecule, HSAS1, HSAS, CD171, CAML1

验证数据展示

  • IF Staining of SH-SY5Y using 84034-5-RR (same clone as 84034-5-PBS)

    IF Staining of SH-SY5Y using 84034-5-RR (same clone as 84034-5-PBS)

    Immunofluorescent analysis of (4% PFA) fixed SH-SY5Y cells using L1CAM antibody (84034-5-RR, Clone: 240978A7 ) at dilution of 1:250 and CoraLite®488-Conjugated Goat Anti-Rabbit IgG(H+L) (SA00013-2). This data was developed using the same antibody clone with 84034-5-PBS in a different storage buffer formulation.

Planning an IHC experiment? We recommend our IHCeasy L1CAM Ready-To-Use IHC Kit. L1CAM primary antibody included.

产品信息

The immunogen of 84034-5-PBS is L1CAM Fusion Protein expressed in E. coli.

Tested Applications IF/ICC, Indirect ELISA Application Description
Tested Reactivity human
Immunogen Fusion Protein 种属同源性预测
Host / Isotype Rabbit / IgG
Class Recombinant
Type Antibody
Full Name L1 cell adhesion molecule
Synonyms L1 cell adhesion molecule, HSAS1, HSAS, CD171, CAML1
Calculated Molecular Weight 1257 aa, 140 kDa
GenBank Accession NumberBC126229
Gene Symbol L1CAM
Gene ID (NCBI) 3897
Conjugate Unconjugated
Form Liquid
Purification MethodProtein A purfication
UNIPROT IDP32004
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

L1CAM, also known as NCAM-L1 or CD171, is a cell adhesion molecule of the immunoglobulin superfamily. It is a 200-220 kDa transmembrane glycoprotein composed of six Ig-like domains and five fibronectin type III repeats followed by a transmembrane region and a highly conserved cytoplasmic tail (PMID: 3412448; 22796939). L1CAM is primarily expressed in the nervous system and is involved in neuron-neuron adhesion, neurite fasciculation, outgrowth of neurites, cerebellar granule cell migration, neurite outgrowth on Schwann cells and interactions among epithelial cells of intestinal crypts (PMID: 3412448; 10767310). L1CAM is overexpressed in many human cancers and is often associated with bad prognosis (PMID: 27267927; 26111503).