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  • Featured Product
  • KD/KO Validated

L2HGDH Polyclonal antibody, PBS Only

L2HGDH Polyclonal Antibody for WB, IHC, Indirect ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse, rat

Applications

WB, IHC, Indirect ELISA

Conjugate

Unconjugated

Cat no : 15707-1-PBS

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Synonyms

验证数据展示

  • WB analysis using 15707-1-AP (same clone as 15707-1-PBS)

    WB analysis using 15707-1-AP (same clone as 15707-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 15707-1-AP (L2HGDH antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 15707-1-PBS in a different storage buffer formulation.

  • IHC staining of human liver cancer using 15707-1-AP (same clone as 15707-1-PBS)

    IHC staining of human liver cancer using 15707-1-AP (same clone as 15707-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human liver cancer tissue slide using 15707-1-AP (L2HGDH antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 15707-1-PBS in a different storage buffer formulation.

  • IHC staining of human liver cancer using 15707-1-AP (same clone as 15707-1-PBS)

    IHC staining of human liver cancer using 15707-1-AP (same clone as 15707-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human liver cancer tissue slide using 15707-1-AP (L2HGDH antibody) at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 15707-1-PBS in a different storage buffer formulation.

产品信息

15707-1-PBS targets L2HGDH in WB, IHC, Indirect ELISA applications and shows reactivity with human, mouse, rat samples.

Tested Applications WB, IHC, Indirect ELISA Application Description
Tested Reactivity human, mouse, rat
Immunogen L2HGDH fusion protein Ag8382 种属同源性预测
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Full Name L-2-hydroxyglutarate dehydrogenase
Synonyms
Calculated Molecular Weight463aa,50 kDa; 441aa,49 kDa
Observed Molecular Weight 45 kDa
GenBank Accession NumberBC006117
Gene Symbol L2HGDH
Gene ID (NCBI) 79944
RRIDAB_2133202
Conjugate Unconjugated
Form Liquid
Purification MethodAntigen affinity purification
UNIPROT IDQ9H9P8
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

L2HGDH(L-2-hydroxyglutarate dehydrogenase, mitochondrial) is also named as duranin, C14orf160 and belongs to the L2HGDH family. The putative L2HGDH is predicted to be targeted to the mitochondria where its mitochondrial targeting sequence is presumably removed(PMID:16005139). Defects in L2HGDH are the cause of L-2-hydroxyglutaric aciduria (L2HGA). It has 2 isoforms produced by alternative splicing with the molecular weight of 50 kDa and 48 kDa. L2HGDH also can be detected as ~45kD due to the 51aa transit peptide cleaved.