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LAG-3 Recombinant antibody, PBS Only

LAG-3 Recombinant Antibody for WB,Indirect ELISA

Host / Isotype

Rabbit / IgG

Reactivity

Human, Mouse

Applications

WB,Indirect ELISA

Conjugate

Unconjugated

CloneNo.

1F14

Cat No : 80867-1-PBS

Print datasheet

Synonyms

CD223, FDC, LAG 3, LAG3, LAG-3, lymphocyte activation gene 3, Protein FDC

验证数据展示

  • WB analysis of CTLL-2 using 80867-1-RR (same clone as 80867-1-PBS)

    WB analysis of CTLL-2 using 80867-1-RR (same clone as 80867-1-PBS)

    CTLL-2 cells were subjected to SDS PAGE followed by western blot with 80867-1-RR (LAG-3 antibody) at dilution of 1:4000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 80867-1-PBS in a different storage buffer formulation.

产品信息

80867-1-PBS targets LAG-3 in WB, Indirect ELISA applications and shows reactivity with Human, Mouse samples.

Tested Applications WB,Indirect ELISA
Tested Reactivity Human, Mouse
Immunogen fusion protein 种属同源性预测
Host / Isotype Rabbit / IgG
Class Recombinant
Type Antibody
Full Name lymphocyte-activation gene 3
Synonyms CD223, FDC, LAG 3, LAG3, LAG-3, lymphocyte activation gene 3, Protein FDC
Calculated Molecular Weight57 kDa
Observed Molecular Weight60 kDa
GenBank Accession NumberNM_002286
Gene Symbol LAG3
Gene ID (NCBI) 3902
Conjugate Unconjugated
Form Liquid
Purification MethodProtein A purification
UNIPROT IDP18627
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.

背景介绍

LAG-3, also known as CD223, is an immune checkpoint molecule that regulates both T-cell activation and homeostasis. LAG-3 is expressed on activated T cells, NK cells, regulatory T cells, and plasmacytoid dendritic cells. It is a CD4-related molecule that binds MHC class II. LAG-3 plays an important role in modulating T cell expansion and function, and blockade of LAG-3 with monoclonal antibodies can augment T cell function. (PMID: 15634887; 21086108; 28783703)