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  • Featured Product
  • KD/KO Validated

LATS1 Monoclonal antibody, PBS Only

LATS1 Monoclonal Antibody for WB, Indirect ELISA

Host / Isotype

Mouse / IgG1

Reactivity

Human

Applications

WB, Indirect ELISA

Conjugate

Unconjugated

CloneNo.

2A8F1

Cat no : 66569-1-PBS

Print datasheet

Synonyms

h warts, LATS1, WARTS, WARTS protein kinase, wts

验证数据展示

  • WB analysis using 66569-1-Ig (same clone as 66569-1-PBS)

    WB analysis using 66569-1-Ig (same clone as 66569-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 66569-1-Ig (LATS1 antibody) at dilution of 1:5000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 66569-1-PBS in a different storage buffer formulation.

  • WB analysis of HepG2 using 66569-1-Ig (same clone as 66569-1-PBS)

    WB analysis of HepG2 using 66569-1-Ig (same clone as 66569-1-PBS)

    WB result of LATS1 antibody (66569-1-Ig; 1:300; incubated at room temperature for 1.5 hours) with sh-Control and sh-LATS1 transfected HepG2 cells. This data was developed using the same antibody clone with 66569-1-PBS in a different storage buffer formulation.

  • WB analysis of HepG2 using 66569-1-Ig (same clone as 66569-1-PBS)

    WB analysis of HepG2 using 66569-1-Ig (same clone as 66569-1-PBS)

    HepG2 cells were subjected to SDS PAGE followed by western blot with 66569-1-Ig (LATS1 antibody) at dilution of 1:2000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 66569-1-PBS in a different storage buffer formulation.

产品信息

66569-1-PBS targets LATS1 in WB, Indirect ELISA applications and shows reactivity with Human samples.

Tested Applications WB, Indirect ELISA Application Description
Tested Reactivity Human
Immunogen LATS1 fusion protein Ag11140 种属同源性预测
Host / Isotype Mouse / IgG1
Class Monoclonal
Type Antibody
Full Name LATS, large tumor suppressor, homolog 1 (Drosophila)
Synonyms h warts, LATS1, WARTS, WARTS protein kinase, wts
Calculated Molecular Weight 15 kDa, 127 kDa
Observed Molecular Weight 140-150 kDa, 120 kDa
GenBank Accession NumberBC015665
Gene Symbol LATS1
Gene ID (NCBI) 9113
Conjugate Unconjugated
Form Liquid
Purification MethodProtein G purification
UNIPROT IDO95835
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

LATS1(Large tumor suppressor homolog 1) is also named as WARTS and belongds to the AGC Ser/Thr protein kinase family. The gene encodes a highly conserved (from fly to human) protein kinase that plays a crucial role in the prevention of tumor formation by controlling the progression of mitosis. The expression of both long(170 kDa) and short lats1 isoforms(120 kDa) in vertebrate retinal cells raises the possibility that these lats1 proteins may act as negative key regulators of the cell cycle each of them performing a unique role (PMID:15777619). In mammalian cells, LATS1 was phosphorylated in a cell cycle-dependent manner and complexed with CDC2 in early mitosis (PMID:9988268). LATS1 also can be detected as 120 kDa and 140-150 kDa, and play a key role in the regulation of Hippo pathway (PMID: 27940445).