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LC3-mHTT-IN-AN1

LC3-mHTT-IN-AN1 是一种 mHTT-LC3 接头化合物，可与突变亨廷顿蛋白 (mHTT) 和 LC3B 相互作用。 它将 mHTT 靶向自噬体以等位基因选择性方式降低培养的亨廷顿病小鼠神经元中的 mHTT 水平。

CAS号

486443-73-6

分子式

C15H9Br2NO3

主要靶点

ATTECs|Others|Autophagy

仅限科研使用

Cat No : CM04940

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Synonyms

验证数据展示

  • CAS No.: 486443-73-6

    LC3-mHTT-IN-AN1
    CAS#: 486443-73-6

产品信息

LC3-mHTT-IN-AN1 is a mHTT-LC3 linker compound that interacts with both mutant huntingtin protein (mHTT) and LC3B. LC3-mHTT-IN-AN1 targeted mHTT to autophagosomes reduces the levels of mHTT in an allele-selective manner in cultured Huntington disease (HD) mouse neurons.

CAS号 486443-73-6
分子式 C15H9Br2NO3
主要靶点 ATTECs|Others|Autophagy
主要通路 其他|PROTAC|自噬
分子量 411.04
纯度 97.26%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名

体外活性

LC3-mHTT-IN-AN1 targeted mHTT to autophagosomes, reduced mHTT levels in an allele-selective manner, and rescued disease-relevant phenotypes in cells and in vivo in fly and mouse models of Huntington's disease.

溶解度

DMSO:120 mg/ml(291.94 mM),Sonification is recommended.

参考文献

1.Li Z, et al. Allele-selective lowering of mutant HTT protein by HTT-LC3 linker compounds. Nature. 2019 Nov;575(7781):203-209.

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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