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LDHA-IN-3

LDHA-IN-3 (1-(phenylseleno)-4-(trifluoromethyl) benzene) 是一种有效的非竞争性乳酸脱氢酶(LDHA) 抑制剂，IC50值为 145.2 nM。LDHA-IN-3 是一种硒苯化合物，可用于研究癌症。

CAS号

227010-33-5

分子式

C13H9F3Se

主要靶点

Dehydrogenase

仅限科研使用

Cat No : CM11483

Print datasheet

Synonyms

PSTMB|1-(phenylseleno)-4-(trifluoromethyl) benzene

验证数据展示

  • CAS No.: 227010-33-5

    LDHA-IN-3
    CAS#: 227010-33-5

产品信息

LDHA-IN-3 is a potent non-competitive lactate dehydrogenase (LDHA) inhibitor with an IC50 value of 145.2 nM.LDHA-IN-3 is a selenobenzene compound that can be used in cancer research.

CAS号 227010-33-5
分子式 C13H9F3Se
主要靶点 Dehydrogenase
主要通路 代谢
分子量 301.17
纯度 99.77%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名 PSTMB|1-(phenylseleno)-4-(trifluoromethyl) benzene

靶点活性

LDHA:145.2 nM (IC50)

体外活性

LDHA-IN-3 (PSTMB) (0~500 μM; 48 h; MCF-7 cells) has cytotoxic effects.[1] PSTMB (0.01~1 μM) has a dose-dependent inhibitory effect on LDHA activity. PSTMB (0~0.5 μM) inhibits LDHA activity in Michaelis-Menten and Lineweaver-Burk plots.[1] PSTMB (30 and 50 μM; HT29 cells) induces ROS production and mitochondrial damage.[1] PSTMB efficiently binds to LDHA protein. PSTMB induces intrinsic pathway-mediated apoptosis in cancer cells through the production of mitochondrial ROS.[1]

溶解度

DMSO:30.11 mg/mL (100 mM),Sonification is recommended.

参考文献

1.Kim EY, et al. A Novel Lactate Dehydrogenase Inhibitor, 1-(Phenylseleno)-4-(Trifluoromethyl) Benzene, Suppresses Tumor Growth through Apoptotic Cell Death. Sci Rep. 2019;9(1):3969. Published 2019 Mar 8.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

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