验证数据展示
产品信息
10785-1-PBS targets LDLR in WB, IHC, IF/ICC, IP, Indirect ELISA applications and shows reactivity with human, mouse samples.
经测试应用 | WB, IHC, IF/ICC, IP, Indirect ELISA Application Description |
经测试反应性 | human, mouse |
免疫原 | LDLR fusion protein Ag1236 种属同源性预测 |
宿主/亚型 | Rabbit / IgG |
抗体类别 | Polyclonal |
产品类型 | Antibody |
全称 | low density lipoprotein receptor |
别名 | LDL receptor, FHC, FH |
计算分子量 | 95 kDa |
观测分子量 | 100-160 kDa |
GenBank蛋白编号 | BC014514 |
基因名称 | LDLR |
Gene ID (NCBI) | 3949 |
ENSEMBL Gene ID | ENSG00000130164 |
RRID | AB_2281164 |
偶联类型 | Unconjugated |
形式 | Liquid |
纯化方式 | Antigen affinity purification |
UNIPROT ID | P01130 |
储存缓冲液 | PBS only , pH 7.3 |
储存条件 | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
LDLR (low density lipoprotein receptor) is a member of the LDL receptor gene family and is involved in receptor-mediated endocytosis of specific ligands. The LDLR is a cell surface glycoprotein that scavenges LDL from the blood and regulates plasma LDL cholesterol. The cytoplasmic domain of the LDL receptor is necessary for the receptor to cluster in coated pits, which promotes the rapid endocytosis of bound LDL. The protein is highly glycosylated through N- and O-linkages and thus migrates at 100 to 160 kDa bands on SDS-PAGE.